Carbamazepine
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B-cell aplasia: case report An adult woman in her early 20s [age at the time of reaction onset not clearly stated] developed B-cell aplasia during carbamazepine treatment for recurrent seizures. The woman had developed recurrent seizures at the age of 21 years, which were initially treated with phenytoin. However, phenytoin was stopped due to drug toxicity. Her phenytoin therapy was then switched to controlled-release carbamazepine 400mg twice daily [route not stated] in May 2001. Six months following initiation of carbamazepine, her absolute lymphocyte count had decreased from a normal baseline level to 1084 /µL, and the lymphocyte subset had low B-cells count of 9 /µL. She had low serum IgG (274 mg/dL), IgM (13 mg/dL), and undetectable IgA (
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