Carbamazepine
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Carbamazepine Alopecia and psoriasiform eruptions: case report A 52-year-old woman developed alopecia and palmoplantar psoriasiform eruptions during treatment with carbamazepine for facial pain. The woman began receiving carbamazepine 200mg three times daily for severe facial pain. One month later, she was diagnosed with acoustic schwannoma, and began experiencing psoriasiform eruptions on her soles and palms. After another month, she began developing alopecia, then presented 1 month later. A physical examination revealed diffuse hair loss on the scalp and the palmoplantar areas exhibited thick hyperkeratotic plaques. A hair-pull test showed easy hair extraction. The woman’s carbamazepine dosage was reduced to 200mg once daily after carbamazepine was suspected of inducing the symptoms. One week after dosage tapering, the psoriasiform eruptions began improving. The palmoplantar lesions also began resolving, and 4 weeks after the dosage decrease, her alopecia regressed. She underwent surgery for the acoustic schwannoma 2 months later. After stopping the carbamazepine, she experienced spontaneous hair regrowth and resolution of the skin eruptions. Author comment: "Since the suspected drug reactions in our patient improved immediately after the tapering of medication, carbamazepine should be considered a possible causative agent of hair loss and palmoplantar psoriasiform eruptions." Oh SH, et al. Concurrence of palmoplantar psoriasiform eruptions and hair loss during carbamazepine treatment. Acta Dermato-Venereologica 88: 532-533, No. 5, 801124469 2008 - South Korea
0114-9954/10/1228-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 15 Nov 2008 No. 1228
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