CardIAc: an open-source application for myocardial strain analysis
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ORIGINAL ARTICLE
CardIAc: an open-source application for myocardial strain analysis Ariel Hernán Curiale1,2
· Agustín Bernardo2,3 · Rodrigo Cárdenas1,2 · German Mato1,2,3
Received: 13 June 2020 / Accepted: 2 November 2020 © CARS 2020
Abstract Purpose This paper presents CardIAc, an open-source application designed as an alternative to commercial software for left ventricle myocardial strain quantification in short-axis cardiac magnetic resonance images. The aim is to provide a useful extension for myocardial strain analysis that can be easily adapted to incorporate different strategies of motion tracking to improve the strain accuracy. In this way, users with programming skills can easily modify the code and adjust the program’s performance according to their own scientific or clinical requirements. The software is intended for research and clinical use is not advised. Methods CardIAc was developed as a 3D Slicer extension for an easy installation and usability. The main contribution of this article is to provide a general workflow, going from data and segmentation loading, 3D heart modeling, analysis and several options for visualization of the myocardial strain. Results CardIAc strain feature was evaluated on a public dataset (Cardiac Motion Analysis Challenge—STACOM 2011) of 15 volunteers, and a synthetic one generated from this real dataset. Results on the real dataset show that cardIAc achieves suitable accuracy for myocardial motion estimation with a median error of 3.66 mm. In particular, global strain curves show strong correlation with the bibliography for healthy patients and similar approaches. On the other hand, results on the synthetic dataset show a mean global error of 4.07%, 7.76% and 8.18% for circumferential, radial and longitudinal strain. Conclusion This paper introduces a new open-source application for strain analysis distributed under a BSD-style open-source license. Results demonstrate the capability and merits of the proposed application for strain analysis. Keywords Cardiac quantification · Strain · Strain rate · Open source · 3D Slicer extension
Introduction Early diagnostic and management of cardiac insufficiencies for people with cardiovascular disease or who are at high cardiovascular risk is of paramount importance to improve their life quality. The analysis of static and dynamic features such as left ventricular mass (LVM), the ejection fraction (EF) and the regional deformation of the heart (strain and strain rate) have proved to be of paramount importance for
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Ariel Hernán Curiale [email protected] http://www.curiale.com.ar
1
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
2
Departamento de Física Médica, Centro Atómico Bariloche e Instituto Balseiro, Av. Bustillo 9500, R8402AGP San Carlos de Bariloche, Río Negro, Argentina
3
Comisión Nacional de Energía Atómica (CNEA), Buenos Aires, Argentina
the study of abnormal cardiac behavior. For example, the study of the regional deformation of the heart currently play
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