Cardiac fibroblast activation detected by Ga-68 FAPI PET imaging as a potential novel biomarker of cardiac injury/remode
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Department of Cardiology and Vascular Medicine, University of Essen Medical School, West German Heart and Vascular Center Essen, University Duisburg-Essen, Essen, Germany b ¨t Mu ¨ nchen, Department of Nuclear Medicine, School of Medicine, Technische Universita Munich, Germany c ¨ r Herz-Kreislauf-Forschung e.V.), Partner Site Munich Heart DZHK (Deutsches Zentrum fu Alliance, Munich, Germany d Department of Nuclear Medicine, Medical Faculty, University Hospital Essen, University of Duisburg-Essen, Essen, Germany e Department of Radiotherapy, University Hospital Essen, University Duisburg-Essen, Essen, Germany f Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Hospital Essen, Essen, Germany g Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany h University Hospital Essen, Institute for Diagnostic and Interventional Radiology and Neuroradiology, University of Duisburg-Essen, Essen, Germany Received Jan 25, 2020; accepted Apr 14, 2020 doi:10.1007/s12350-020-02307-w
Background. Fibroblast activation protein (FAP) as a specific marker of activated fibroblasts can be visualized by positron emission tomography (PET) using Ga-68-FAP inhibitors (FAPI). Gallium-68-labeled FAPI is increasingly used in the staging of various cancers. In addition, the first cases of theranostic approaches have been reported. In this work, we describe the phenomenon of myocardial FAPI uptake in patients who received a Ga-68 FAPI PET for tumor staging. Method and results. Ga-68 FAPI PET examinations for cancer staging were retrospectively analyzed with respect to cardiac tracer uptake. Standardized uptake values (SUV) were correlated to clinical covariates in a univariate regression model. From 09/2018 to 11/2019 N = 32 patients underwent FAPI PET at our institution. Six out of 32 Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12350-020-02307-w) contains supplementary material, which is available to authorized users. The authors of this article have provided a PowerPoint file, available for download at SpringerLink, which summarizes the contents of the paper and is free for re-use at meetings and presentations. Search for the article DOI on SpringerLink.com. The authors have also provided an audio summary of the article, which is available to download as ESM, or to listen to via the JNC/ASNC Podcast.
Translators: Zhuo He, B.S., College of Computing, Michigan Technological UniversityMin Zhao, M.D., Ph.D., Department of Nuclear Medicine, Xiangya HospitalWeihua Zhou, Ph.D., College of Computing, Michigan Technological University. Reprint requests: C. Rischpler, Department of Nuclear Medicine, Medical Faculty, University Hospital Essen, University of DuisburgEssen, Essen, Germany; [email protected] J Nucl Cardiol 1071-3581/$34.00 Copyright © 2020 The Author(s).
Siebermair et al Cardiac fibroblast activation detected by Ga-68 FAPI PET
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