Cardiac Fibrosis and Heart Failure: Cause or Effect?
The unique biology of cardiac fibroblasts and related cells, such as cardiac myofibroblasts and valvular interstitial cells, distinguish them from other fibroblastic cells, a concept that is only beginning to be widely appreciated. Further, the natu
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Series Editor Naranjan S. Dhalla Winnipeg, Canada Volume 1: S. K. Cheema (ed), Biochemistry of Atherosclerosis Volume 2: S. W. Schaffer and M-Saadeh Suleiman (eds), Mitochondria: The Dynamic Organelle Volume 3: A. K. Srivastava and M. B. Anand- Srivastava (eds), Signal Transduction in the Cardiovascular System in Health and Disease Volume 4: B. Ostadal and N. S. Dhalla (eds), Cardiac Adaptations-Molecular Mechanisms Volume 5: B. I. Jugdutt and N. S. Dhalla (eds), Cardiac Remodeling-Molecular Mechanisms Volume 6: J. L. Mehta and N. S. Dhalla (eds), Biochemical Basis and Therapeutic Implications of Angiogenesis Volume 7: S. Chakraborti and N. S. Dhalla (eds), Proteases in Health and Disease Volume 8: N. S. Dhalla and S. Chakraborti (eds), Role of Proteases in Cellular Dysfunction Volume 9: B. Turan and N. S. Dhalla (eds), Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms Volume 10: P. S. Tappia and N. S. Dhalla (eds), Phospholipases in Heaith and Disease Volume 11: G. D. Lopaschuk and N. S. Dhalla (eds), Cardiac Energy Metabolism in Health and Disease Volume 12: K. Ahmed, O-G. Issinger and R. Szyszka (eds), Protein Kinase CK2 Cellular Function in Normal and Disease States Volume 13: J. T. Wigle and I. M. C. Dixon (eds), Cardiac Fibrosis and Heart Failure: Cause or Effect?
This new series, Advances in Biochemistry in Heath and Disease, will focus on developments in biochemical research with implications for health and disease. The series will consist of original edited volumes, monographs, references, proceedings. The series will publish a minimum of three volumes a year. More information about this series at http://www.springer.com/series/7064
Ian M.C. Dixon • Jeffrey T. Wigle Editors
Cardiac Fibrosis and Heart Failure: Cause or Effect?
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Editors Ian M.C. Dixon Institute of Cardiovascular Sciences St. Boniface Hospital Research Centre Department of Physiology and Pathophysiology University of Manitoba Winnipeg Canada
Jeffrey T. Wigle Institute of Cardiovascular Sciences St. Boniface Hospital Research Centre Department of Biochemistry and Medical Genetics University of Manitoba Winnipeg Canada
Advances in Biochemistry in Health and Disease ISBN 978-3-319-17436-5 ISBN 978-3-319-17437-2 (eBook) DOI 10.1007/978-3-319-17437-2 Library of Congress Control Number: 2015941510 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement,
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