Cardiac Gene Therapy Methods and Protocols
This detailed book provides methodological information on cardiac gene delivery, from classic to state-of-the-art technologies and techniques. Efficient, cardiac-specific, and safe vectors, as well as refined vector delivery methods, are key for succ
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Kiyotake Ishikawa Editor
Cardiac Gene Therapy Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Cardiac Gene Therapy Methods and Protocols
Edited by
Kiyotake Ishikawa Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Editor Kiyotake Ishikawa Cardiovascular Research Center Icahn School of Medicine at Mount Sinai New York, NY, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6586-1 ISBN 978-1-4939-6588-5 (eBook) DOI 10.1007/978-1-4939-6588-5 Library of Congress Control Number: 2016959002 © Springer Science+Business Media New York 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Rapid evolutions in vector technologies and identification of key molecular targets have facilitated the use of gene therapy as a vital approach for treating cardiovascular diseases. In the past decade, there has been substantial progress in clinical translation of cardiac gene therapy. Nevertheless, recent early clinical trials using gene therapy as a therapeutic approach to improve heart failure have shown neutral results, and the difficulty of transferring the genes to human hearts has become ever more recognized. Efficient, cardiac-specific, and safe vectors, as well as refined vector delivery methods, are key for successful cardiac gene transfer and eventually for improving patients’ outcomes. Newer vectors and more efficient vector delivery methods have the potential to dramatically improve gene transduction efficacy, while novel gene manipulation techniques enforce the therapeu
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