Viral Vectors for Gene Therapy Methods and Protocols
The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than D
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
Viral Vectors for Gene Therapy Methods and Protocols
Edited by
Otto-Wilhelm Merten Généthon, Evry, France
Mohamed Al-Rubeai School of Chemical and Bioprocess Engineering, and Conway Institute for Biomolecuar and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland
Editors Otto-Wilhelm Merten Généthon, Evry France [email protected]
Mohamed Al-Rubeai School of Chemical & Bioprocess Engineering and Conway Institute for Biomolecular and Biomedical Research, University College Dublin Belfield, Dublin, Ireland [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-61779-094-2 e-ISBN 978-1-61779-095-9 DOI 10.1007/978-1-61779-095-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011926456 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area. The first human gene therapy protocol was conducted in 1990 by W. French Anderson and showed promising results. Over the following years, more than 1,500 gene therapy protocols were approved for clinical trials, illustrating the rapid growth of this field. Furthermore, with the sequencing of the human genome and the development of advanced technologies for the identification of genes and their function, the number of candidate diseases for gene therapy has continued to increase. However, the efficient transfer of a therapeutic gene into human cells depends upon the technology used for gene therapy. A number of delivery systems are in use, which either involve physi
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