CCN Proteins in Health and Disease An Overview of the Fifth Internat
The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity
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Annick Perbal · Masaharu Takigawa · Bernard Perbal Editors
CCN Proteins in Health and Disease An Overview of the Fifth International Workshop on the CCN Family of Genes
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Editors Annick Perbal International CCN Society Palais du Grand Large 35000 Saint Malo France [email protected]
Masaharu Takigawa Department of Biochemistry and Molecular Dentistry Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan [email protected]
Bernard Perbal R&D L’Oreal USA Clark, NJ 07066 USA [email protected]
ISBN 978-90-481-3778-7 e-ISBN 978-90-481-3779-4 DOI 10.1007/978-90-481-3779-4 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010921918 © Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1 A Recent Breakthrough in the CCN Field: Functional Interactions Between CCN2 and CCN3 are Uncovered . . . . . . Bernard Perbal
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2 Report on the Fifth International Workshop on the CCN Family of Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . A. E. Irvine, B. Perbal, and H. Yeger
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3 Asking the Right Questions: What Can the Structure of the CCN Protein Domains Tell Us? . . . . . . . . . . . . . . . . Kenneth P. Holbourn, Bernard Perbal, and K. Ravi Acharya
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4 Nucleophosmin/B23: A Multifunctional Regulator that Determines the Fate of CCN2 mRNA . . . . . . . . . . . . . . . . Satoshi Kubota, Yoshiki Mukudai, Harumi Kawaki, Seiji Kondo, Takanori Eguchi, Kumi Sumiyoshi, Toshihiro Ohgawara, Tsuyoshi Shimo, and Masaharu Takigawa 5 The CCN Genes as the “Master” Regulators of Angiogenesis, Vasculogenesis, Fibrogenesis and Cell Differentiation/Fate Specification in Mechanical Force-Driven Developmental Processes and Pathological Events . Mary Hanna and Brahim Chaqour 6 A Monoclonal Antibody Approach to CCN5 Domain Analysis . . Lan Wei, Frank McKeon, Joshua W. Russo, Joan Lemire, and John Castellot 7 Matricellular Protein CCN2 Produced by Tubular Epithelial Cells Plays a Pivotal Role in Renal Fibrogenesis . . . . Hirokazu Okada, Tsutomu Inoue, and Hiromichi Suzuki 8 Cooperative Regulation of Cell Proliferation and Differentiation by CCN2 and CCN3 . . . . . . . . . . . . . . Masaharu Takigawa, Harumi Kawaki, Satoshi Kubota, Karen M. Lyons, and Bernard Perbal
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Contents
9 The Role of CCN3 in Mesenchymal Stem Cells . . . . . . . . . . . Ken-Ichi Katsube
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10 Role of Connective Tissue Growth Factor in Cardiac Fibrosis . . Daiji Kawanami, Saptarsi M. Haldar, and Mukesh K. Jain
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11 Gene Expression
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