CCN Proteins Methods and Protocols
This volume provides a comprehensive guide on the Cyr61 (Cysteine-rich 61) (CCN) family of proteins and genes from basic research to cutting-edge methodologies and state-of-the-art techniques. Chapters details practical tips to overcome any obs
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Masaharu Takigawa Editor
CCN Proteins Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
CCN Proteins Methods and Protocols
Edited by
Masaharu Takigawa Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School/Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Editor Masaharu Takigawa Advanced Research Center for Oral and Craniofacial Sciences Okayama University Dental School/Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama, Japan
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6428-4 ISBN 978-1-4939-6430-7 (eBook) DOI 10.1007/978-1-4939-6430-7 Library of Congress Control Number: 2016951254 © Springer Science+Business Media New York 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface CCN is an acronym that stands for Cyr61 (Cysteine-rich 61)/CCN1, CTGF (connective tissue growth factor)/CCN2, and Nov (nephroblastoma overexpressed)/CCN3, which are the three founder members of this family. This family now comprises six distinctive members with the addition of three more members, namely, WISP (Wnt-induced secreted protein) 1-3/CCN4-6. They are all cysteine-rich secreted proteins and composed of four distinct modules connected in tandem, i.e., IGF binding protein-like, von Willebrand type C, thrombospondin type 1 repeat, and C-terminal modules, except for CCN5, which lacks the CT module. They are known to play roles in fundamental biological processes by serving as multifunctional growth and differentiation regulators that interact physically with various cytokines, extracellular matrice
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