Cell Cycle Deregulation in Cancer
Modern studies of regulation of the cell division cycle were pioneered by Leland Hartwell, Paul Nurse, and Tim Hunt in yeast and marine invertebrates. This work identified proteins termed cyclins that fluxuate in abundance during progression through the c
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Greg H. Enders Editor
Cell Cycle Deregulation in Cancer
Editor Greg H. Enders Fox Chase Cancer Center Department of Medicine 333 Cottman Ave. Philadelphia, PA 19111-2497 USA [email protected]
ISBN 978-1-4419-1769-0 e-ISBN 978-1-4419-1770-6 DOI 10.1007/978-1-4419-1770-6 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010921202 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Contents
Part I
Starting the Cell Division Cycle
1 Escape from Cellular Quiescence . . . . . . . . . . . . . . . . . . Elena Sotillo and Xavier Graña
3
2 Interplay Between Cyclin-Dependent Kinases and E2F-Dependent Transcription . . . . . . . . . . . . . . . . . . Jun-Yuan Ji and Nicholas J. Dyson
23
3 Regulation of Pre-RC Assembly: A Complex Symphony Orchestrated by CDKs . . . . . . . . . . . . . . . . . . . . . . . . A. Kathleen McClendon, Jeffry L. Dean, and Erik S. Knudsen
43
Part II
Proliferation Under Duress
4 Mitotic Checkpoint and Chromosome Instability in Cancer . . . . Haomin Huang and Timothy J. Yen
59
5 Mitotic Catastrophe . . . . . . . . . . . . . . . . . . . . . . . . . . Jeremy P.H. Chow and Randy Y. C. Poon
79
6 p53, ARF, and the Control of Autophagy . . . . . . . . . . . . . . Robert D. Hontz and Maureen E. Murphy
97
Part III Long-Term Proliferation 7 Regulation of Self-Renewing Divisions in Normal and Leukaemia Stem Cells . . . . . . . . . . . . . . . . . . . . . . Andrea Viale and Pier Giuseppe Pelicci 8 Maintenance of Telomeres in Cancer . . . . . . . . . . . . . . . . Eros Lazzerini Denchi 9 The Senescence Secretome and Its Impact on Tumor Suppression and Cancer . . . . . . . . . . . . . . . . . . . . . . . Alyssa Kennedy and Peter D. Adams
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Part IV
Contents
Applications in Preventing
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