Cell Engineering Apoptosis
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Cell Engineering Volume 4 Editor-in-Chief Professor Mohamed Al-Rubeai School of Chemical Engineering, The University of Birmingham, Edgbaston, Birmingham, U.K. Editorial Board Dr Hansjorg Hauser GBF, Braunschweig, Germany Professor Michael Betenbaugh Johns Hopkins University, Baltimore, U.S.A. Professor Martin Fussenegger Swiss Federal Institute of Technology Zurich, Switzerland Dr Nigel Jenkins Bioprocess Research & Development, Lilly Research Laboratories, Indianapolis, U.S.A. Professor Caroline MacDonald University of Paisley, Paisley, U.K. Dr Otto-Wilhelm Merten A.F.M.-Genethon 11, Gene Therapy Program, Evry, France
The titles published in this series are listed at the end of this volume
CELL ENGINEERING Vol. 4: Apoptosis Edited by
Mohammed Al-Rubeai School of Chemical Engineering, The University of Birmingham, Edgbaston, Birmingham, U.K. and
Martin Fussenegger Swiss Federal Institute of Technology, Zurich, Switzerland
KLUWER ACADEMIC PUBLISHERS NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW
eBook ISBN: Print ISBN:
1-4020-2217-4 1-4020-2216-6
©2005 Springer Science + Business Media, Inc.
Print ©2004 Kluwer Academic Publishers Dordrecht All rights reserved
No part of this eBook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher
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CONTENTS
LIST OF CONTRIBUTORS 1. CASPASE REGULATION AT THE MOLECULAR LEVEL H. Kaufmann and M. Fussenegger 2. THE BCL-2 FAMILY A. Petch and M. Al-Rubeai
vii 1
25
3. THE IGF-1 RECEPTOR IN CELLS SURVIVAL: SIGNALLING AND REGULATION 49 P. A. Kiely, D. M. O’Gorman, A. Lyons and R. O’Connor 4. APOPTOSIS IN HEPATOCYTES N.T. Mukwena and M. Al-Rubeai 5. PROGRAMMED CELL DEATH IN PLANTS DURING DEVELOPMENT AND STRESS RESPONSES S. Panter and M. Dickman 6. A SYSTEMS VIEW OF CELL DEATH J. Varner and M. Fusseneger 7. THE ROLE OF CASPASES IN APOPTOSIS AND THEIR INHIBITION IN MAMMALIAN CELL CULTURE T. M. Sauerwald and. M.J. Betenbaugh
93
107
153
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8. IMPROVEMENT OF INDUSTRIAL CELL CULTURE PROCESSES BY CASPASE- 9 DOMINANT NEGATIVE AND OTHER APOPTOTIC INHIBITORS 211 J. van de Goor 9. THERAPEUTIC SMALL MOLECULE INHIBITORS OF BCL-2 P. Beauparlant and G. C. Shore
223
vi
10. APOPTOSIS CONTOL BASED ON DOWN-REGULATING THE INHIBITOR-OF-APOPTOSIS (IAP) PROTEINS: XIAP ANTISENSE AND OTHER APPROACHES 239 E. LaCasse 11. MONITORING OF APOPTOSIS A. Ishaque and M. Al-Rubeai
281
12. MOLECULAR IMAGING OF PROGRAMMED CELL DEATH; FROM BASIC MECHANISMS TO CLINICAL APPLICATIONS 307 B. L. J. H. Kietselaer, C. P. M. Reutelingsperger and L. Hofstra INDEX
329
LIST OF CONTRIBUTORS Mohamed Al-Rubeai The University of Birmingham Birmingham, UK Pierre Beauparlant Gemin X Biotechnilogies Inc. Montreal, Quebec, Canada Michael Betenbaugh The Johns Hopkins University Baltimore, Maryland, USA Martin Dickman University of Nebraska-Linco
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