Cell Therapy for Brain Injury
This is a review of state-of-the-art cell therapy in the treatment of stroke, traumatic brain injuries and neonatal stroke and hypoxia-ischemia using a variety of cells ranging from bone marrow derived stem cells and mesenchymal stem cells to induced plur
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David C. Hess Editor
Cell Therapy for Brain Injury
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Editor Dr. David C. Hess Department of Neurology Georgia Regents University Augusta, GA, USA
ISBN 978-3-319-15062-8 ISBN 978-3-319-15063-5 (eBook) DOI 10.1007/978-3-319-15063-5 Library of Congress Control Number: 2015937202 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1 Introduction to Cell Therapy in Brain Injury����������������������������������������� 1 David C. Hess 2 Cell-Based Therapeutics in Stroke: An Industry Perspective��������������� 11 Martin M. Bednar 3 Autologous Mesenchymal Stem Cell Therapy in Patients with Stroke������������������������������������������������������������������������������� 21 Oh Young Bang 4 Treatment of Autologous Bone Marrow Mononuclear Cells for Acute and Subacute Stroke����������������������������������������������������������������� 37 Yukiko Kasahara, Tomohiro Matsuyama and Akihiko Taguchi 5 Clinical Development of MultiStem® for Treatment of Injuries and Diseases of the Central Nervous System���������������������������� 47 Robert W. Mays 6 Intra-arterial Approaches to Stem Cell Therapy for Ischemic Stroke������������������������������������������������������������������������������������ 65 Vikram Jadhav, Pallab Bhattacharya and Dileep R. Yavagal 7 Neural Stem Cells in Stroke: Intracerebral Approaches������������������������ 91 Nathan C. Manley, Ricardo L. Azevedo-Pereira, Tonya M. Bliss and Gary K. Steinberg 8 The CTX Human Neural Stem Cell Line and the PISCES Stroke Trial�������������������������������������������������������������������� 111 Keith W. Muir and John D. Sinden
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Contents
9 Induced Pluripotent Stem Cells as a Cell-Based Therapeutic in Stroke......................................................
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