Cell Therapy for Perinatal Brain Injury
This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These disea
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Haruo Shintaku Akira Oka Makoto Nabetani Editors
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Cell Therapy for Perinatal Brain Injury
Haruo Shintaku • Akira Oka • Makoto Nabetani Editors
Cell Therapy for Perinatal Brain Injury
Editors Haruo Shintaku Department of Pediatrics Osaka City University Graduate School of Medicine Osaka, Japan
Akira Oka Department of Pediatrics University of Tokyo Tokyo, Japan
Makoto Nabetani Department of Pediatrics Yodogawa Christian Hospital Osaka, Japan
ISBN 978-981-10-1411-6 ISBN 978-981-10-1412-3 (eBook) https://doi.org/10.1007/978-981-10-1412-3 Library of Congress Control Number: 2018930911 © Springer Nature Singapore Pte Ltd. 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
Perinatal brain injury is a leading cause of cerebral palsy (CP), often resulting in lifelong disabilities. Because more than 90% of CP patients today survive into adulthood, the economic and social burdens associated with support for the patients and their families are significant, and therefore pathophysiological understanding of the disease and development of effective therapies are urgent public health needs. Perinatal hypoxic–ischemic encephalopathy (HIE) is an important cause of brain injury resulting from reduced cerebral blood flow at birth that leads to hypoxia and hypoglycemia in brain cells. Impaired uptake of glutamate by brain neurons results in intracellular calcium accumulation, which ultimately causes irreversible damage. To date, hypothermia therapy has been the only effective treatment for HIE to prevent the development of CP. A recent publication in the United States [1], however, indicated benefits of aut
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