Self-Healing Collagen-Based Hydrogel for Brain Injury Therapy
Hydrogels derived from biopolymers, also called biohydrogels, have shown potential for brain injury therapy due to their tunable physical, chemical, and biological properties. Among different biohydrogels, those made from collagen type I are very promisin
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Self-Healing Collagen-Based Hydrogel for Brain Injury Therapy Raquel de la Cruz and David Díaz Díaz
Contents 1 Introduction 2 Collagen and Collagen Hydrogels 3 In Vitro Studies 4 In Vivo Studies 5 Concluding Remarks References
Abstract Hydrogels derived from biopolymers, also called biohydrogels, have shown potential for brain injury therapy due to their tunable physical, chemical, and biological properties. Among different biohydrogels, those made from collagen type I are very promising candidates for the reparation of nervous tissues due to its biocompatibility, noncytotoxic properties, injectability, and self-healing ability. Moreover, although collagen does not naturally occur in the brain, it has been demonstrated that collagen type I, which resides in the basal lamina of the subventricular zone in adults, supports neural cell attachment, axonal growth, and cell proliferation due to its intrinsic content of specific cell-signaling domains. This chapter summarizes the most relevant results obtained from both in vitro and in vivo studies using self-healing biohydrogels based on collagen type I as key component in the field of neuroregeneration.
R. de la Cruz and D. D. Díaz (*) Departamento de Química Orgánica, Universidad de La Laguna, La Laguna, Tenerife, Spain Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, La Laguna, Tenerife, Spain Institut für Organische Chemie, Universität Regensburg, Regensburg, Germany e-mail: [email protected]
R. de la Cruz and D. D. Díaz
Keywords Brain therapy · Central nervous system · Collagen · Hydrogel · Regeneration
Abbreviations 2D 3D BBB bFGF BMSC CLG3/HLP CNS cRGD CSPG DGEA DRG ECM EGF ESC FAK FGF-2 FITC FN G3P GDNF GRP HA hMSC LG3 LN LP MCAO MSC mTGase NeuN NGC NGF NPC NSC PC12 PCR PNS ReNcell RGD RGDT SAPNS
Two dimensional Three dimensional Blood-brain barrier Basic fibroblast growth factor Bone marrow-derived mesenchymal stem cell Collagen-binding LG3/histidine-tagged LP Central nervous system Cyclo(RGD-D-Phe-Val) Chondroitin sulfate proteoglycans Aspartic acid-glycine-glutamic acid-alanine Dorsal root ganglion/ganglia Extracellular matrix Epidermal growth factor Embryonic stem cell Focal adhesion kinase Fibroblast growth factor-2 Fluorescein isothiocyanate Fibronectin Glyceraldehyde 3-phosphate Glial cell line-derived neurotrophic factor Human glial-restricted precursor Sodium hyaluronate (hyaluronic acid) Human marrow stromal cell Peptide LG3 Laminin Peptide FNTPSIEKP Middle cerebral artery occlusion Mesenchymal stem cell Microbial transglutaminase Neural nuclear protein Nerve guidance channel Nerve growth factor Neural progenitor cell Neural stem cells Pheochromocytoma cell Polymerase chain reaction Peripheral nervous system Neural progenitor cell Arginylglycylaspartic acid Arginylglycylaspartic acid-threonine Self-assembling peptide nanofiber scaffolds
Self-Healing Collagen-Based Hydrogel for Brain Injury Therapy
SC SEM
Schwann cell Scanning electron microscopy
1 Introduction The central nervous system (CNS) i
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