Cessation of bisphosphonates, followed by antibacterials, surgery and/or hyperbaric oxygen, is effective for osteonecros
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■ Cessation of bisphosphonates, followed by antibacterials, surgery and/or hyperbaric oxygen, is effective for osteonecrosis of the jaw induced by bisphosphonates, concludes a retrospective analysis by researchers from Greece. They evaluated data for 60 patients with bisphosphonate-induced osteonecrosis of the jaw, who received treatment which included withdrawal of bisphosphonate therapy, long-term antibacterials,* sequestrectomy or debridement, or hyperbaric oxygen therapy. A total of seven patients were treated with cessation of bisphosphonate therapy for > 6 months, followed by surgery and long-term antibacterial therapy, with or without hyperbaric oxygen treatment; all seven patients developed complete wound healing following these treatment protocols. However, surgical intervention and antibacterial therapy, without cessation of bisphosphonates for > 6 months, resulted in disease recurrence; antibacterial therapy plus surveillance resulted in progressive necrosis. * consisting of clindamycin, amoxicillin/clavulanic acid and benzylpenicillin Magopoulos C, et al. Osteonecrosis of the jaws due to bisphosphonte use. A review of 60 cases and tretment proposals. American Journal of 801091141 Otolaryngology 28: 158-163, No. 3, May-Jun 2007
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