Challenges and Opportunities for Respiratory Syncytial Virus Vaccines

Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis a

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Larry J. Anderson Barney S. Graham Editors

Challenges and Opportunities for Respiratory Syncytial Virus Vaccines

Current Topics in Microbiology and Immunology Volume 372

Series editors Klaus Aktories Medizinische Fakultät, Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Abt. I Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany Richard W. Compans Department of Microbiology and Immunology, Emory University, 1518 Clifton Road, CNR 5005, Atlanta, GA 30322, USA Max D. Cooper Department of Pathology and Laboratory Medicine, Georgia Research Alliance, Emory University, 1462 Clifton Road, Atlanta, GA 30322, USA Jorge E. Galan Boyer Ctr. for Molecular Medicine, School of Medicine, Yale University, 295 Congress Avenue, room 343, New Haven, CT 06536-0812, USA Yuri Y. Gleba ICON Genetics AG, Biozentrum Halle, Weinbergweg 22, 06120 Halle, Germany Tasuku Honjo Faculty of Medicine, Department of Medical Chemistry, Kyoto University, Sakyo-ku, Yoshida, Kyoto 606-8501, Japan Yoshihiro Kawaoka School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA Bernard Malissen Centre d’Immunologie de Marseille-Luminy, Parc Scientifique de Luminy, Case 906, 13288 Marseille Cedex 9, France Fritz Melchers Max Planck Institute for Infection Biology, Charitéplatz 1, 10117 Berlin, Germany Michael B. A. Oldstone Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA Rino Rappuoli Novartis Vaccines, Via Fiorentina 1, Siena 53100, Italy Peter K. Vogt Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC-239, La Jolla, CA 92037, USA Honorary Editor: Hilary Koprowski (deceased) Biotechnology Foundation, Inc., Ardmore, PA, USA

For further volumes: http://www.springer.com/series/82

Larry J. Anderson Barney S. Graham •

Editors

Challenges and Opportunities for Respiratory Syncytial Virus Vaccines Responsible series editor: Richard W. Compans

123

Editors Larry J. Anderson Department of Pediatrics and Children’s Healthcare of Atlanta Emory University Atlanta, GA USA

ISSN 0070-217X ISBN 978-3-642-38918-4 DOI 10.1007/978-3-642-38919-1

Barney S. Graham Vaccine Research Center National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, MD USA

ISSN 2196-9965 (electronic) ISBN 978-3-642-38919-1 (eBook)

Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2013955565  Springer-Verlag Berlin Heidelberg 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter de