Changes in serum parameters associated with iron metabolism in male rat exposed to lead
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ORIGINAL PAPER
Changes in serum parameters associated with iron metabolism in male rat exposed to lead Minoo Moshtaghie & Pedram Malekpouri & Mohammad Reza Dinko & Ali Asghar Moshtaghie
Received: 11 November 2011 / Accepted: 11 September 2012 # University of Navarra 2012
Abstract Due to the severe hazardous influences of lead (Pb2+) on iron-related diseases, the effects of Pb2+ on serum parameters associated with iron metabolism have been studied in this project. Male Wistar rats weighing 200–250 g were treated with Pb2+ for the short and long period of times. The animals received daily intraperitoneal injection of 100 mg Pb2+ kg−1 body weight (BW) for 5 days and 4 mgkg−1 BW of Pb2+ for 30 and 45 days, respectively. The results show that when animals were treated with both low and high concentrations of Pb2+, serum iron concentration decreased markedly, by 23.2, 32.8, and 39.9 %, while the sera TIBC and transferrin concentrations M. Moshtaghie Department of Environment and Energy, Science and Research Branch, Islamic Azad University, Tehran, Iran P. Malekpouri (*) Young Researchers Club, Science and Research Branch, Islamic Azad University, Tehran, Iran e-mail: [email protected] M. R. Dinko Department of Biochemistry, School of Pharmacy, Isfahan University of Medical Science, Isfahan, Iran A. A. Moshtaghie Department of Biochemistry, School of Basic Science, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
increased significantly (p < 0.05). Following shortand long-term exposures to Pb2+, the percentage of serum transferrin saturation was also decreased in comparison with the untreated control group (p < 0.05). Concentrations of serum copper and ceruloplasmin following Pb2+ treatments also reduced significantly (p
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