Changes in the Levels of Interleukin-17 Between Atopic and Non-atopic Children with Mycoplasma pneumoniae Pneumonia
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ORIGINAL ARTICLE
Changes in the Levels of Interleukin-17 Between Atopic and Non-atopic Children with Mycoplasma pneumoniae Pneumonia Zhi-Hua Wang,1,3 Xin-Min Li,2 Yu-Shui Wang,1 and Ze-Yang Guo1
Abstract—As previous study showed that Mycoplasma pneumoniae (MP) induced a cellular immune response associated with interleukin-17 (IL-17), we designed this study to explore IL-17 in MP pneumonia patients with atopic sensitization and 144 patients were evaluated and divided into three groups: atopic MP pneumonia group (n = 38), non-atopic MP pneumonia group (n = 74), and atopic non-MP pneumonia group (n = 32). Serum IL-17 was measured at admission acute phase and at recovery phase. We found IL-17 levels only in the atopic MP pneumonia group that were significantly higher at recovery phase than at acute phase, and its levels were also higher in the atopic MP pneumonia group than the other two groups at clinical recovery phase. In addition, acute asthma attack was higher in the atopic MP pneumonia group. Therefore, IL-17 should be related with asthma and it can be a good marker warning an acute asthma attack in atopic MP pneumonia. Necessary measures can be taken as prevention. KEY WORDS: interleukin-17; Mycoplasma pneumoniae pneumonia; atopy; asthma.
INTRODUCTION Mycoplasma pneumoniae (MP) is a common cause of community-acquired pneumonia, mainly in children and young adults, and is well known to cause a wide variety of respiratory and extra-pulmonary diseases [1, 2]. In addition to its role as a cause of community-acquired pneumonia, one of the most significant pulmonary manifestations of MP exposure is pediatric wheezing and acute exacerbation of asthma [3–5]. Previous studies have demonstrated that MP infection results in generation of T helper type 2 (Th2) allergic inflammation and induces airway hypersensitivity during MP pneumonia in atopic children [6–8]. Kurai D et al.
reported that MP extract induces a cellular immune response associated with interleukin-17 (IL-17), leading to lung inflammation and lung injury [9]. However, defining a clear cause-and-effect relationship between MP infection and asthma has been elusive. New data provide evidence that IL-17 could play an important role in the development of childhood asthma [10, 11]. In addition, It could drive neutrophil influx into the airways and upregulate Th2 cell-mediated eosinophilic airway inflammation [12, 13]. Therefore, this study was undertaken to detect the serum levels of IL-17 in MP pneumonia patients with and without atopic sensitization, aiming to investigate the relation between IL-17 and asthma attack in atopic children with MP pneumonia.
1
Department of Pediatrics, Tianjin Nankai Hospital, Nankai Sanwei Road, Tianjin, 300100, China 2 Department of Pediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China 3 To whom correspondence should be addressed at Department of Pediatrics, Tianjin Nankai Hospital, Nankai Sanwei Road, Tianjin, 300100, China. E-mail: [email protected]
METHODS Study Subjects and
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