Changes induced by metabolic surgery on the main components of glucose/insulin system in patients with diabetes and obes
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SHORT COMMUNICATION
Changes induced by metabolic surgery on the main components of glucose/insulin system in patients with diabetes and obesity Elisabetta Rinaldi1 · Maria Grazia Zenti1 · Maddalena Trombetta1 · Giulia Ceradini1 · Anna Altomari1 · Maria Linda Boselli1 · Lorenza Santi1 · Marco Battistoni2 · Riccardo C. Bonadonna3,4 · Enzo Bonora1 Received: 6 October 2020 / Accepted: 3 November 2020 © Springer-Verlag Italia S.r.l., part of Springer Nature 2020
Introduction Bariatric surgery is able to induce remission of type 2 diabetes (T2D). Several studies reported an improvement of insulin sensitivity after surgery [1], but data about insulin secretion and insulin clearance are less abundant and somewhat controversial [2, 3]. Aim of our study was to assess the changes of the determinants of glucose regulation, i.e., insulin secretion, insulin sensitivity and insulin clearance in a group of T2D patients with obesity one month and over 1 year after metabolic surgery.
Methods Ten (M/F = 5/5) patients with T2D and obesity (mean ± SD: duration of diabetes: 5.6 ± 1.3 years, BMI: 45.2 ± 1.8 Kg/ m2) candidate for sleeve gastrectomy (SG) or gastric bypass (RYGB) were recruited for the protocol approved by the Local Ethical Committee (CE 2170) and registered as NCT01767441. Remission of diabetes was defined according Riccardo C. Bonadonna and Enzo Bonora jointly supervised this study. Managed by Massimo Porta. * Elisabetta Rinaldi [email protected] 1
Section of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Stefani, 1, 37126 Verona, Italy
2
Division of Bariatric Surgery, Department of Surgery, University Hospital of Verona, Verona, Italy
3
Department of Medicine and Surgery, University of Parma, Parma, Italy
4
Division of Endocrinology and Metabolic Diseases, Azienda Ospedaliera Universitaria, Parma, Italy
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