Effects of Electroacupuncture on Metabolic Changes in Motor Cortex and Striatum of 6-Hydroxydopamine-Induced Parkinsonia
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hinese Journal of Integrative Medicine
Available online at link.springer.com/journal/11655 Journal homepage: www.cjim.cn/zxyjhen/zxyjhen/ch/index.aspx E-mail: [email protected]
Original Article
Effects of Electroacupuncture on Metabolic Changes in Motor Cortex and Striatum of 6-HydroxydopamineInduced Parkinsonian Rats LI Min, WANG Ke, SU Wen-ting, JIA Jun, and WANG Xiao-min Objective:: To explore the possible underlying mechanism by investigating the effect of ABSTRACT Objective electroacupuncture (EA) treatment on the primary motor cortex and striatum in a unilateral 6-hydroxydopamine Methods:: Male Sprague-Dawley rats were randomly (6-OHDA) induced rat Parkinson's disease (PD) model. Methods divided into sham group (n =16), model group (n =14), and EA group (n =14). EA stimulation at Dazhui (GV 14) and Baihui (GV20) was applied to PD rats in the EA group for 4 weeks. Behavioral tests were conducted to evaluate the effectiveness of EA treatment. Metabolites were detected by 7.0 T proton nuclear magnetic Results:: Following 4 weeks of EA treatment in PD model rats, the abnormal behavioral impairment resonance. Results induced by 6-OHDA was alleviated. In monitoring changes in metabolic activity, ratios of myoinositol/creatine (Cr) and N-acetyl aspartate (NAA)/Cr in the primary motor cortex were significantly lower at the injected side than the non-injected side in PD rats (P =0.024 and 0.020). The ratios of glutamate + glutamine (Glx)/Cr and NAA/Cr in the striatum were higher and lower, respectively, at the injected side than the non-injected side (P =0.046 and 0.008). EA treatment restored the balance of metabolic activity in the primary motor cortex and striatum. In addition, the taurine/Cr ratio and Glx/Cr ratio were elevated in the striatum of PD model rats compared to sham-lesioned rats (P =0.026 and 0.000). EA treatment alleviated the excessive glutamatergic transmission by down-regulating the striatal Glx/Cr ratio (P =0.001). The Glx/Cr ratio was negatively correlated Conclusions:: EA treatment is able with floor plane spontaneous locomotion in PD rats (P =0.027 and P =0.0007). Conclusions to normalize the metabolic balance in the primary motor cortex and striatum of PD rats, which may contribute to its therapeutic effect on motor deficits. The striatal Glx/Cr ratio may serve as a potential indicator of PD and a therapeutic target of EA treatment. KEYWORDS electroacupuncture, magnetic resonance spectroscopy, motor cortex, striatum, Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder, which is characterized by progressive loss of dopamine (DA) that is normally released from the dopaminergic neurons in the substantia nigra compacta (SNc). (1) Consistent evidence has demonstrated that the motor cortex and striatum are important central sites for PD therapy.(1,2) The physical therapies, including deep brain stimulation and transcranial magnetic stimulation, have been rapidly developed during the past years.(3,4) These therapies are believed to target brain regions including the
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