Characteristics of corneal high-order aberrations in adolescents with mild to moderate myopia
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RESEARCH ARTICLE
Open Access
Characteristics of corneal high-order aberrations in adolescents with mild to moderate myopia Xu Zhang1†, Jin-Hui Ma2†, Xin Xi3* and Lin Guan4
Abstract Background: This study investigated the characteristics of corneal higher-order aberrations (HOAs) of the anterior surface, posterior surface, and total cornea in adolescents with mild to moderate myopia. Methods: A total of 183 patients with myopia (183 eyes) aged 8 to 18 years were enrolled in this study. The axial length (AL) of the eyes was measured by an IOL-Master, and corneal curvatures (K-values) and HOAs were measured by a Pentacam anterior segment diagnostic analyzer. Results: Results of this study showed that the anterior, posterior and total corneal horizontal coma Z31 were − 0.1249 ± 0.105 μm, 0.0009 ± 0.001 μm, and − 0.1331 ± 0.116 μm, respectively; the anterior, posterior and total corneal vertical coma Z3− 1 were − 0.0212 ± 0.164 μm, 0.0003 ± 0.043 μm, and − 0.0216 ± 0.168 μm, respectively; and spherical aberration (SA) Z40 values were 0.2244 ± 0.091 μm, 0.1437 ± 0.029 um, and 0.1889 ± 0.090 μm, respectively. Total corneal Z31 was statistically correlated with posterior corneal astigmatism (K2b − K1b) (p = 0.038). Total corneal Z3− 1 was correlated with anterior corneal astigmatism (K2f − K1f) (p = 0.027). Anterior, posterior, and total corneal Z40 were correlated with anterior and posterior corneal curvature (K1f, K2f, K1b, K2b) (p = 0.001). Posterior corneal Z40b was also significantly correlated with AL. Conclusions: In adolescents with mild to moderate myopia, the posterior corneal surface shape may play a compensatory role in the balance of corneal aberrations, and the posterior corneal SA tended to become less negative as the AL increased. The corneal coma may also play a compensatory role in posterior corneal surface astigmatism, which was valuable for the treatment for improving visual quality. This conclusion still needs to be verified. Keywords: Corneal high-order aberration, Myopia, Ocular axial length, Corneal curvatures, Orthokeratology
Background The prevalence of myopia is high in East Asia, and approximately one in six of the world’s population is myopic [1, 2]. The prevention and control of adolescent myopia are of global importance because of its high burden on vision health. Some scholars believe that the decline in retinal imaging quality caused by high-order aberrations (HOAs) may be a factor that influences the development of myopia * Correspondence: [email protected] † Xu Zhang and Jin-Hui Ma contributed equally to this work. 3 Central Laboratory, Affiliated Hospital of Hebei University, No 212. Yuhuadong Road, Lianchi District, Baoding 071000, China Full list of author information is available at the end of the article
in children [3–7]. In a study conducted by Zhang et al., HOA without spherical aberration (SA) was correlated with the progression of myopia [4], and it was predicted that HOA is a risk factor for myopia progression. Animal studies showed that a form of deprivation or lens-in
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