Chinese Herbal Medicine-Derived Products for Prevention or Treatment of Diseases Affecting Quality of Life
Chinese herbal medicine (CHM) has been used for several thousands of years to treat human illness, which makes CHM the best source to provide valuable and unique information for modern drug discovery and development. Development of CHM products as adjunct
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Chinese Herbal Medicine-Derived Products for Prevention or Treatment of Diseases Affecting Quality of Life Kuo-Hsiung Lee, Susan L. Morris-Natschke, Yu Zhao, and Katie Musgrove
Abstract Chinese herbal medicine (CHM) has been used for several thousands of years to treat human illness, which makes CHM the best source to provide valuable and unique information for modern drug discovery and development. Development of CHM products as adjunct therapies to augment the efficacy and offset the toxicity of Western medicine is an excellent approach for rapid advancement into US FDAapproved new drugs. Developing CHM products as high-quality dietary supplements must particularly emphasize standardization through qualitative and quantitative quality controls on single herbs and multiple herbs of the prescription formulas by using the most advanced scientific technology, especially toxicity profile testing. A combination of advanced medicinal chemistry and natural products chemistry, coupled with cutting-edge life science technology, will play a very important role for converting CHM products, especially the pure single active principles, through modification and synthesis into clinical trial candidates very efficiently and effectively. This chapter presents ten case studies of promising new drug discovery resulting from CHM-derived products: compounds from Curcuma longa (Jiang Huang), Antrodia camphorata (Chang-ku), Apium graveolens (Han Qin), Momordica charantia (Ku Gua), Monascus purpureus (Hong Chi), Astragalus membranaceus (Huang Chi), Scutellaria decoction (Huang Chin Tang), Eucommia ulmoides (Tu Chung), Ligusticum wallichii (Chuan Chiung), and Lycium barbarum (Kou Chi Tzu).
K.-H. Lee (*) Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan e-mail: [email protected] S.L. Morris-Natschke • Y. Zhao • K. Musgrove Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, USA © Springer Science+Business Media Singapore 2016 H.-S. Tsay et al. (eds.), Medicinal Plants - Recent Advances in Research and Development, DOI 10.1007/978-981-10-1085-9_1
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Keywords Chinese herbal medicine (CHM) • Drug discovery and development • Disease prevention and treatment • Medicinal chemistry • Natural products chemistry • Traditional Chinese medicine (TCM)
Abbreviations Ach AIDS ANS ATP BDFI CD CHM COX CRF DNA EDHF EGFR-TKI FDA FRET FTIR GAP GCP GI GLP GMP GRAS HBV HCV HIV HIV-1 HPLC HPV IC50 IL IND iNOS IOIP IV LBP MALDI-TOF MS mcIRBP
Acetylcholine Acquired immunodeficiency syndrome 1-anilino-8-naphthalene-sulfonate Adenosine triphosphate Bioactivity-directed fractionation and isolation Circular dichroism Chinese herbal medicine Cyclooxygenase Cancer-related fatigue Deoxyribonucleic acid Endothelium-derived hyperpolarizing factor Epidermal growth factor receptor tyro
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