Chondroitin sulfate-based smart hydrogels for targeted delivery of oxaliplatin in colorectal cancer: preparation, charac
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Chondroitin sulfate‑based smart hydrogels for targeted delivery of oxaliplatin in colorectal cancer: preparation, characterization and toxicity evaluation Kashif Barkat1 · Mahmood Ahmad2 · Muhammad Usman Minhas3 · Ikrima Khalid4 · Nadia Shamshad Malik5 Received: 24 October 2019 / Revised: 24 October 2019 / Accepted: 8 December 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract The present study was performed to evaluate the effect of chondroitin sulfate, acrylic acid and ammonium peroxodisulfate in formulation of a novel biodegradable and pH-sensitive hydrogel for targeted delivery of an anticancer drug oxaliplatin. The synthesized hydrogel was characterized by FTIR, thermal analysis and SEM. FTIR indicated efficient grafting. Thermogravimetric analysis depicted thermodynamically stable behavior. SEM of developed hydrogels revealed rough surface. pHsensitivity was confirmed through swelling dynamics and drug release behavior at pH 1.2 and pH 7.4. Acute oral toxicity study indicated no mortality or any signs of acute toxicity during the whole observation period. Hence, the designed polymeric network could be considered safe and is potential candidate for colon targeting of oxaliplatin in colorectal cancer. * Mahmood Ahmad [email protected] Kashif Barkat [email protected] Muhammad Usman Minhas [email protected] Ikrima Khalid [email protected] Nadia Shamshad Malik [email protected] 1
Faculty of Pharmacy, The University of Lahore, Lahore, Punjab 54000, Pakistan
2
Faculty of Pharmacy, University of Central Punjab, Lahore, Punjab 54000, Pakistan
3
College of Pharmacy, University of Sargodha, Sargodha, Punjab, Pakistan
4
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan
5
Department of Pharmacy, Capital University of Science and Technology (CUST), Islamabad, Pakistan
13
Vol.:(0123456789)
Polymer Bulletin
Keywords Chondroitin sulfate · Acrylic acid · Oxaliplatin · Colorectal cancer
Introduction Small intestine provides a favorable environment for absorption of drug, but in some instances the drug needs to be targeted to colon in order to treat colonic disease and also control degradation-related conditions, delayed release of drugs, systemic delivery of protein and peptide drugs, etc. [1]. Colon-targeted drug delivery is essential and relatively new concept for drugs absorption because it proposes neutral pH and long residence time of drug, thus increasing the drug absorption [2]. In colon targeting, dosage form should be designed in such a way that it inhibits the drug release in upper gastrointestinal tract and releasing it in colonic region. In delivery of drug to the colon, lot of merits would be attained in order to improve safety and reduce toxicity when local or systemic chronic diseases going to be treated [3]. The colon-specific diseases are inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, irritable bowel syndromes (IBS), helminths and color
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