Chromosomal imbalances in nasopharyngeal carcinoma: a meta-analysis of comparative genomic hybridization results
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BioMed Central
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Chromosomal imbalances in nasopharyngeal carcinoma: a meta-analysis of comparative genomic hybridization results Xin Li1,2, Ena Wang1, Ying-dong Zhao3, Jia-Qiang Ren1, Ping Jin1, KaiTai Yao2 and Francesco M Marincola*1 Address: 1Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, 20892, USA, 2Department of pathology and Cancer research Institute, College of Basic Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, PR. China and 3Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Email: Xin Li - [email protected]; Ena Wang - [email protected]; Ying-dong Zhao - [email protected]; Jia-Qiang Ren - [email protected]; Ping Jin - [email protected]; Kai-Tai Yao - [email protected]; Francesco M Marincola* - [email protected] * Corresponding author
Published: 19 January 2006 Journal of Translational Medicine 2006, 4:4
doi:10.1186/1479-5876-4-4
Received: 08 November 2005 Accepted: 19 January 2006
This article is available from: http://www.translational-medicine.com/content/4/1/4 © 2006 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Nasopharyngeal carcinoma (NPC) is a highly prevalent disease in Southeast Asia and its prevalence is clearly affected by genetic background. Various theories have been suggested for its high incidence in this geographical region but to these days no conclusive explanation has been identified. Chromosomal imbalances identifiable through comparative genomic hybridization may shed some light on common genetic alterations that may be of relevance to the onset and progression of NPC. Review of the literature, however, reveals contradictory results among reported findings possibly related to factors associated with patient selection, stage of disease, differences in methodological details etc. To increase the power of the analysis and attempt to identify commonalities among the reported findings, we performed a meta-analysis of results described in NPC tissues based on chromosomal comparative genomic hybridization (CGH). This meta-analysis revealed consistent patters in chromosomal abnormalities that appeared to cluster in specific "hot spots" along the genome following a stage-dependent progression.
Background Nasopharyngeal carcinoma (NPC) is a Epstein-Barr virusassociated cancer [1] highly prevalent in Southeast Asia and especially southern China where it occurs at a prevalence about a 100-fold higher compared with other populations not at risk [2,3]. Although environmental factors may contribute to this geographical association [4], the high prevalence of NPC in U.S. immigrants suggests a genetic infl
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