The prognostic role of prognostic nutritional index in nasopharyngeal carcinoma: A systematic review and meta-analysis
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ORIGINAL ARTICLE
The prognostic role of prognostic nutritional index in nasopharyngeal carcinoma: A systematic review and meta‑analysis Min Tang1 · Zhongxiong Jia2 · Ju Zhang1 Received: 30 June 2020 / Accepted: 22 September 2020 © Japan Society of Clinical Oncology 2020
Abstract Purpose The prognostic utility of the prognostic nutritional index (PNI) in nasopharyngeal carcinoma (NPC) has never been systematically reviewed. Therefore, we performed this meta-analysis. Methods We performed comprehensive research via Embase, PubMed, Web of Science and the Cochrane Library. The pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were applied to explore the relationship between PNI and overall survival (OS), progression-free survival (PFS), locoregional failure-free survival (LRFFS), distant metastasis-free survival (DMFS) and clinical features. Both univariate analysis (UVA) and multivariate analysis (MVA) were used. Results A total of 8 eligible studies including 3631 patients were ultimately enrolled. A low PNI level was significantly associated with a shorter OS [(HR 2.06, P
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