Chromosomal terminal methylation status is associated with gut microbiotic alterations
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Chromosomal terminal methylation status is associated with gut microbiotic alterations Toyoki Maeda1 · Takahiko Horiuchi1 · Naoki Makino1 Received: 11 July 2020 / Accepted: 14 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract We explored the association of fecal bacterial species and somatic telomere changes in patients with chronic disease. The results showed that the length of the combined range of telomere and the methylated subtelomere was correlated with the increase of bacteria species and the numerical superiority of certain strains in feces, the increase of streptococci in men and women, and the increase of E. coli specifically in women. These results suggest that the aging status reflected by telomere length and/or demethylation of neighboring regions correlate with intestinal conditions which influences the proportion of the intestinal microbial population. Shortened telomere length and subtelomeric demethylation status are thought to represent the degree of aging and the accelerating stage of aging velocity, respectively. Hence, the observed biased microbial status is considered to be associated with advanced stage or acceleration phase of biological aging. Keywords Aging · Telomere · Genomic methylation · Gut microbiota · Postmenopause
Introduction Telomeres are the structure at the ends of chromosomes that consists of conserved repetitive DNA sequences and surrounding protein components [1]. Telomere DNA length is shortened in all cell divisions due to an incomplete DNA duplication mechanism. Elder peripheral leukocytes have shorter telomeres [2]. This shortening of somatic telomere associated with aging is accelerated in various pathophysiological conditions including diabetes mellitus, ischemic heart disease, neurodegenerative disorders, smoking and increased daily mental stress [3–8]. We have been investigating the association between somatic telomeric or subtelomeric parameters and clinical variables, to find specific clinical factors for genomic aging. We have reported that somatic telomere length and subtelomeric methylation status correlate with body composition protein levels Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11010-020-03892-7) contains supplementary material, which is available to authorized users. * Toyoki Maeda [email protected]‑u.ac.jp 1
The Department of Internal Medicine, Kyushu University Beppu Hospital, 4546 Tsurumihara Beppu, Oita 874‑0838, Japan
[9], clinical laboratory variables related to life-long cumulation of immunological responses [10], and electrocardiac variables [11]. And outpatients with short telomeres are more likely to be hospitalized [12]. Moreover, people with short telomeres tend to suffer from heart disease and infectious diseases leading to reduced life expectancy [13]. Thus, aging-related somatic changes are reflected in clinical parametric variables that correlate with telomeric changes. DNA methylation status in the genomic DNA region adjacent to t
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