Cilia and Nervous System Development and Function
Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function o
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Kerry L. Tucker • Tamara Caspary Editors
Cilia and Nervous System Development and Function
Editors Kerry L. Tucker Anatomy and Cell Biology University of Heidelberg Heidelberg, Germany
Tamara Caspary Human Genetics Emory University School of Medicine Atlanta, Georgia, USA
ISBN 978-94-007-5807-0 ISBN 978-94-007-5808-7 (eBook) DOI 10.1007/978-94-007-5808-7 Springer Dordrecht Heidelberg New York London Library of Congress Control Number: 2013930057 © Springer Science+Business Media Dordrecht 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Acknowledgements
K.L.T. and T.C. would like to thank Martijn Roelandse at Springer-Verlag for his patient support of the whole project. K.L.T is especially grateful to Frau Sara Doll at the Institute of Anatomy at the University of Heidelberg for enthusiastic assistance with research into the history of cilia investigations in the last several centuries.
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Contents
Introduction ...................................................................................................
ix
1 Primary and Motile Cilia: Their Ultrastructure and Ciliogenesis .......... Sigrid Hoyer-Fender
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2 Primary Cilia, Sonic Hedgehog Signaling, and Spinal Cord Development ....................................................................
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