Ciliary muscle dimensions measured by swept-source optical coherence tomography in eyes with primary open-angle glaucoma
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ORIGINAL PAPER
Ciliary muscle dimensions measured by swept-source optical coherence tomography in eyes with primary open-angle glaucoma and healthy eyes Bachar Kudsieh . Jose´ Ignacio Ferna´ndez-Vigo . Hang Shi . Lucı´a De Pablo Go´mez de Lian˜o . ´ ngel Ferna´ndez-Vigo Jose´ Marı´a Ruiz-Moreno . Julia´n Garcı´a-Feijo´o . Jose´ A
Received: 2 December 2019 / Accepted: 27 April 2020 Ó Springer Nature B.V. 2020
Abstract Purpose To compare in vivo swept-source optical coherence tomography (SS-OCT) measurements of the ciliary muscle (CM) in patients with primary openangle glaucoma (POAG) and healthy subjects, and examine correlations between CM dimensions and several covariates. Methods This was a cross-sectional study of the right eyes of 181 subjects: 89 POAG patients and 92 healthy subjects. Using the Triton SS-OCT device (Topcon, Tokyo, Japan), CM length (CML), area (CMA) and
B. Kudsieh J. M. Ruiz-Moreno Department of Ophthalmology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain B. Kudsieh (&) J. I. Ferna´ndez-Vigo ´ . Ferna´ndez-Vigo H. Shi J. A Centro Internacional de Oftalmologı´a Avanzada, Zurbano 71, 28010 Madrid, Spain e-mail: [email protected] J. I. Ferna´ndez-Vigo H. Shi J. Garcı´a-Feijo´o Department of Ophthalmology, San Carlos Clinical Hospital, Health Research Institute (IdISSC), Universidad Complutense, OFTARED, Madrid, Spain L. De Pablo Go´mez de Lian˜o Department of Ophthalmology, Hospital Universitario Doce De Octubre, Madrid, Spain ´ . Ferna´ndez-Vigo J. A Department of Ophthalmology, Universidad de Extremadura, Badajoz, Spain
thickness measured 1000 lm (CMT1), 2000 lm (CMT2) and 3000 lm (CMT3) from the scleral spur were determined in the temporal and nasal quadrants. POAG patients were subjected to visual field (VF) and peripapillary retinal nerve fiber layer (RNFL) assessment. CM dimensions were then assessed for correlation with VF mean defect (MD), mean RNFL thickness and intraocular pressure (IOP). Results Mean CMLs were 4325 ± 340 lm and 4195 ± 843 lm for the healthy subjects and POAG patients, respectively (p = 0.17). Mean CM thicknesses were CMT1 = 546 ± 56 lm, CMT2 = 326 ± 44 lm and CMT3 = 174 ± 16 lm in the healthy eyes versus CMT1 = 534 ± 108, CMT2 = 332 ± 99 and CMT3 = 183 ± 74 in the POAG eyes, with no significant differences detected (all p C 0.25). In the temporal quadrant, mean CMA was 1.12 ± 0.29 mm2 and 1.15 ± 0.24 mm2 for the healthy and POAG subjects, respectively (p = 0.45). No correlations were observed between CM measurements and RNFL thickness (p C 0.15), IOP or VF MD (p C 0.14) in POAG subjects irrespective of glaucoma severity (p C 0.19). Conclusions While SS-OCT proved useful to measure CM dimensions in vivo, these dimensions did not differ between healthy individuals and POAG subjects. In the patients with POAG, no correlations were detected between CM dimensions and VF, RNFL or IOP.
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Int Ophthalmol
Keywords Ciliary body Ciliary muscle Optical coherence tomography Glaucom
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