Cine CMR diastolic function parameters in acute ST-elevation MI (STEMI) patients are associated with cardiac injury and
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Cine CMR diastolic function parameters in acute ST-elevation MI (STEMI) patients are associated with cardiac injury and left ventricular strain Ana Barac1*, Gopal Ghimire2, Jyotshana Shrestha2, Manuel A Gonzalez2, William O Suddath2, Augusto D Pichard2, Lowell F Satler2, Ron Waksman2, Anthon R Fuisz2, Gaby Weissman2 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Objective The aim of this study was to investigate associations between different parameters of diastolic function assessed from cine CMR, biomarkers of cardiac injury and left ventricular function and strain in patients with STEMI. Background Presence of diastolic dysfunction in patients with history of myocardial infarction represents a marker of adverse outcomes. However, its role in acute ST-elevation myocardial infarction (STEMI) is not fully elucidated. Cardiovascular magnetic resonance (CMR) allows quantitative measurement of volumetric changes that occur during diastole and form basis for calculation of different parameters of diastolic function. The relationships between these parameters, LV systolic function and strain, and markers of cardiac injury in STEMI are unknown.
standard echocardiographic views using 2D speckletracking software (2D CPA, TomTec, Germany). All patients had serial troponin values (at least three) measured.
Results Median troponin value was 34ng/mL (IQR 15.8-101.8) and median time from symptom onset to reperfusion was 194 minutes (IQR 158-277). Normalized PFR and DVR 80 were associated with peak troponin I levels (r=-0.36, P=0.049, and r=-0.41, P=0.011 respectively). LV ejection fraction as well as global LV longitudinal strain correlated with nPFR (r=0.432, P=0.017 and r=-0.565, P=0.010 respectively) but the association with DVR 80 was not significant (r=0.277, P=0.18 and r=-0.232,
Methods Thirty patients with acute STEMI undergoing primary PCI were prospectively enrolled and underwent CMR imaging and 2D echocardiography within 48 hours of admission. CMR images were planimetered (Qmass, Medis, The Netherlands) in all slice positions across all temporal phases to calculate diastolic parameters: E/A ratio, peak filling rate (PFR and nPFR-normalized value for stroke volume), time to peak filling rate (TPFR), and diastolic volume recovery (DVR 80 - proportion of diastole required to recover 80% stroke volume). Longitudinal, radial and circumferential strain were assessed from 1 Washington Hospital Center/Georgetown University Hospital, Washington, DC, USA Full list of author information is available at the end of the article
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© 2011 Barac et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Barac et al. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1):P93 http://jcmr-online.com/con
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