Impaired myocardial perfusion on CMR is associated with increased numbers of classical monocytes in STEMI patients treat
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Impaired myocardial perfusion on CMR is associated with increased numbers of classical monocytes in STEMI patients treated by primary PCI Lourens FHJ Robbers1*, Anja M van der Laan2, Robin Nijveldt1, Aernout M Beek1, Ronak Delewi1, Alexander Hirsch2, C Ellen van der Schoot3, Bart J Biemond2, Felix Zijlstra4, Jan J Piek2, Albert C van Rossum1 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Introduction Despite optimal revascularization strategies, STEMI patients often show impaired myocardial tissue reperfusion due to microvascular obstruction. Monocytes, especially the classical monocytes have been suggested to contribute to microvascular obstruction through a complex inflammatory response. Purpose To investigate the relation between the circulating number of classical monocytes and severity of myocardial perfusion impairment in patients with ST-elevated myocardial infarction (STEMI) treated with primary PCI.
tertile) compared to low numbers (lower tertile) of CM (mean relative upslope in upper tertile 7.5 versus mid tertile 5.8 versus lower tertile 5.2, p=0.014). Also, patients with high numbers of CM had a larger infarct size (9.17 vs. 6.51 vs. 3.89 g/m 2 , p
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