Ciprofloxacin-loaded polymeric nanoparticles incorporated electrospun fibers for drug delivery in tissue engineering app
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ORIGINAL ARTICLE
Ciprofloxacin-loaded polymeric nanoparticles incorporated electrospun fibers for drug delivery in tissue engineering applications Cemre Günday 1 & Shivesh Anand 2 & Hikmet Burcu Gencer 3 & Sara Munafò 2,4 & Lorenzo Moroni 2 & Alessandra Fusco 5,6 & Giovanna Donnarumma 5,6 & Claudio Ricci 6 & Pinar Cakir Hatir 3 & Nazende Günday Türeli 1 & Akif Emre Türeli 1 & Carlos Mota 2 & Serena Danti 4,6
# Controlled Release Society 2020
Abstract Presented work focuses on the development of biodegradable polymer nanoparticles loaded with antibiotics as drug delivery systems deposited on electrospun scaffolds for tissue engineering. The innovative ciprofloxacin-loaded poly(DL-lactide-coglycolide) NPs ensure a continuous slow release and high local concentration at the site of action for an optimal therapy. The local delivery of antibiotics as an integrated part of electrospun scaffolds offers an effective, safe, and smart enhancement supporting tissue regeneration. Presented data provides solid scientific evidence for fulfilling the requirements of local nano antibiotic delivery systems with biodegradability and biocompatibility for a wide range of tissue engineering applications, including middle ear tissues (e.g., tympanic membranes) which are subject to bacterial infections. Further characterization of such systems, including in vivo studies, is required to ensure successful transfer from lab to clinical applications.
Keywords Nanoparticles . Electrospinning . Stem cells . Immunomodulation . Regenerative medicine
Introduction Cemre Günday and Shivesh Anand equally contributed to this research article. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13346-020-00736-1) contains supplementary material, which is available to authorized users. * Nazende Günday Türeli [email protected] 1
MJR PharmJet GmbH, Industriestr. 1B, 66802 Überherrn, Germany
2
MERLN Institute for Technology-Inspired Regenerative Medicine, Department of Complex Tissue Regeneration, Maastricht University, 6229 ER Maastricht, The Netherlands
3
Department of Biomedical Engineering, Istanbul Arel University, 34537 İstanbul, Turkey
4
Department of Civil and Industrial Engineering, University of Pisa, 56122 Pisa, Italy
5
Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
6
Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), Florence, Italy
Nano drug delivery systems are being intensively investigated due to the increasing demand on safer, more effective, and lower-cost drug formulations. Nanomedicine has rapidly promoted the development of a large number of new-generation innovative products that reached clinics [1]. A variety of different approaches from polymeric to inorganic nanoparticles (NPs) and lipid to liposome based have been developed as nano drug carriers [2, 3]. Among them, the (bio)polymerbased NP systems are highly accepted and have already shown clinical success. However, ther
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