Circulating sortilin levels are associated with inflammation in patients with moyamoya disease
- PDF / 1,165,194 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 29 Downloads / 177 Views
ORIGINAL ARTICLE
Circulating sortilin levels are associated with inflammation in patients with moyamoya disease Wenxiu Han 1 & Yi Qiao 2 & Hailiang Zhang 1 & Chunmei Geng 1 & Xing Zhu 3 & Dehua Liao 4 & Yujin Guo 1 & Mengqi Yang 1 & Dan Chen 1 & Pei Jiang 1 Received: 12 October 2019 / Accepted: 8 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Systemic inflammation has been implicated in the pathogenesis of moyamoya disease (MMD). Sortilin is a critical regulator of proinflammatory cytokine secretion in several cell types. The present study investigated the association between circulating sortilin and proinflammatory cytokine levels and the occurrence of MMD. Methods Forty-two MMD cases and 76 age- and sex-matched controls were enrolled in this study between January 2018 and June 2019 at the Affiliated Hospital of Jining Medical University. The demographic and clinical characteristics were evaluated, and the circulating serum and cerebrospinal fluid (CSF) levels of sortilin, sortilin-related receptor with A-type repeats (SorLA), and proinflammatory cytokines including C-reactive protein (CRP), interleukin (IL)-6, interferon (IFN)-γ were measured by enzyme-linked immunosorbent assay. Linear regression and correlation analyses were used to estimate the associations between sortilin, SorLA, and proinflammatory cytokine levels. Results MMD patients had higher serum levels of sortilin (P = 0.012), CRP (P = 0.013), IL-6 (P = 0.004), and IFN-γ (P = 0.033) than healthy controls. In MMD patients, serum sortilin was positively correlated with serum proinflammatory cytokines (CRP: r = 0.459, P = 0.0022; IL-6: r = 0.445, P = 0.0032; and IFN-γ: r = 0.448, P = 0.0029) and CSF sortilin (r = 0.440, P = 0.0035); the latter was positively correlated with CSF levels of CRP (r = 0.542, P = 0.0002), IL-6 (r = 0.440, P = 0.0036), and IFN-γ (r = 0.443, P = 0.0033). Conclusions Elevated sortilin level is associated MMD onset and may be a clinically useful biomarker along with proinflammatory cytokine levels. Keywords Sortilin . Inflammation . SorLA . Moyamoya disease
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11011-020-00616-0) contains supplementary material, which is available to authorized users. Wenxiu Han and Yi Qiao are co-first authors and have contributed equally to this work. * Pei Jiang [email protected] 1
Institute of Clinical Pharmacy & Pharmacology, Jining First People’s Hospital, Jining Medical University, 6, Jiankang Road, Jining 272011, China
2
Department of Public Health, Jining Medical University, 272000 Jining, China
3
Department of Medical Engineering, Jining Medical University, 272000 Jining, China
4
Department of Pharmacy, Hunan Cancer Hospital, Central South University, Changsha 410011, China
Introduction Moyamoya disease (MMD) is a chronic cerebrovascular occlusive disease characterized by progressive stenosis in the terminal portion of the internal carotid artery and an abnormal vascular networ
Data Loading...
