Sortilin levels correlate with major cardiovascular events of diabetic patients with peripheral artery disease following
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ORIGINAL INVESTIGATION
Cardiovascular Diabetology Open Access
Sortilin levels correlate with major cardiovascular events of diabetic patients with peripheral artery disease following revascularization: a prospective study Federico Biscetti1,2,3* , Elisabetta Nardella2, Maria Margherita Rando2, Andrea Leonardo Cecchini2, Nicola Bonadia1,4, Piergiorgio Bruno1,5, Flavia Angelini3, Carmine Di Stasi6, Andrea Contegiacomo6, Angelo Santoliquido1,7,8, Dario Pitocco1,7,9, Raffaele Landolfi1,2,7 and Andrea Flex1,2,3,7
Abstract Background: Peripheral artery disease (PAD) represents one of the most relevant vascular complications of type 2 diabetes mellitus (T2DM). Moreover, T2DM patients suffering from PAD have an increased risk of major adverse cardiovascular events (MACE) and major adverse limb events (MALE). Sortilin, a protein involved in apolipoproteins trafficking, is associated with lower limb PAD in T2DM patients. Objective: To evaluate the relationship between baseline serum levels of sortilin, MACE and MALE occurrence after revascularization of T2DM patients with PAD and chronic limb-threatening ischemia (CLTI). Research design and methods: We performed a prospective non-randomized study including 230 statin-free T2DM patients with PAD and CLTI. Sortilin levels were measured before the endovascular intervention and incident outcomes were assessed during a 12 month follow-up. Results: Sortilin levels were significantly increased in individuals with more aggressive PAD (2.25 ± 0.51 ng/mL vs 1.44 ± 0.47 ng/mL, p
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