Cissampelos genus: biological activities, ethnobotanical and phytochemical aspects
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Cissampelos genus: biological activities, ethnobotanical and phytochemical aspects Johnatan Wellisson da Silva Mendes . Walmir Emanuel Miranda Cunha . Fa´bio Fernandes Galva˜o Rodrigues . Edilberto Rocha Silveira . Roberta Da´vila Pereira de Lima . Jose´ Galberto Martins da Costa
Received: 7 August 2019 / Accepted: 2 June 2020 Ó Springer Nature B.V. 2020
Abstract Species of Cissampelos (Menispermaceae) are widely used in folk medicine in various cultures, for the treatment of a wide variety of diseases. Several ethnobotanical studies have reported the use of these species, which, among other benefits, instigated further researches on several pharmacological properties and biologically active compounds present in species of the genus. The objective of this review is to compile and update information about the ethnobotanical, phytochemical and biological studies of species of the Cissampelos genus. Among the officially accepted species, C. pareira, C. mucronata and C. sympodialis were the most reported in all aspects of the research. Their immunomodulatory, anti-inflammatory, antioxidant, antiallergic and antimicrobial properties have already been established. Evidently, a considerable part of these bioactivities is due to the presence of alkaloids, the main constituents of Cissampelos species. Other natural
J. W. da Silva Mendes W. E. M. Cunha F. F. G. Rodrigues R. D. P. de Lima J. G. M. da Costa (&) Departamento de Quı´mica Biolo´gica, Laborato´rio de Pesquisa de Produtos Naturais, Universidade Regional Do Cariri, Rua Coronel Antoˆnio Luı´z, 1161 - Pimenta, Crato, Ceara´ 63105-010, Brazil e-mail: [email protected] E. R. Silveira Departamento de Quı´mica Orgaˆnica E Inorgaˆnica, Universidade Federal Do Ceara´, Campus Do Pici, Bloco 940, Bairro Pici, Fortaleza, Ceara´ 60451-970, Brazil
products such as essential oils, fixed oils, pectins, alcamides, polysaccharides and flavonoids have also been reported. Future investigations on Cissampelos species are necessary, especially regarding pharmacological properties, isolation of substances, mechanism of action and bioavailability in order to provide subsidies for the development of new drugs. Keywords Bioactivities Cissampelos Ethnobotany Phytochemistry Traditional use Abbreviations Ag Antigen ALT Alanine aminotransferase APORFIN Aporphic AV Atrioventricular AZAFLU Azafluorantene BIQ Benzylisoquinolinic BIS-BIQ Bisbenzylisoquinolinic cAMP Adenosina 30 ,50 -monofosfato cı´clico DENV’s Dengue virus serotypes DPPH 2,2-Diphenyl-1-picrylhydrazyl ED Effective dose ELISA Enzyme-linked immunosorbent assay GSH L-glutathione HPLC High performance liquid chromatography Huh-7 Human hepatocyte lineage IC Inhibitory Concentration IFN Interferon
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Ig IL i. p. LC LD LDH LPS MHC MIC MIF MORFIN MTT NSAIDs NO OVA OXOCAN PAF PIR p. o. PROAPORFIN PROTOB PGE PMA SDS-PAGE TNF TROPOLI UV 5-HT
Immunoglobulin Interleukin Intraperitoneal Lethal Concentration Lethal dose Lactate dehydrogenase Lipopolysac
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