Diversity, phytochemical and medicinal potential of the genus Ocimum L. ( Lamiaceae )
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Diversity, phytochemical and medicinal potential of the genus Ocimum L. (Lamiaceae) Eman Maher Zahran . Usama Ramadan Abdelmohsen . Hany Ezzat Khalil . Samar Yehia Desoukey . Mostafa Ahmed Fouad . Mohamed Salah Kamel
Received: 18 November 2019 / Accepted: 29 May 2020 Springer Nature B.V. 2020
Abstract Ocimum, commonly known as Tulsi, is a huge genus within family Lamiaceae, comprising about 64 species of annual to perennial aromatic medicinal herbs with a long history of traditional uses. The aromatic plants of the genus Ocimum have long been used as flavouring agents, as well as diverse medicinal applications. Our comprehensive review covers the published literature through the period from 1961 to April 2019 and provides a complete survey of nearly all the studied species up to date. Additionally, all related taxonomic data, geographical distribution as well as different traditional uses are discussed here in details. The major chemical classes within the genus Ocimum include flavonoids, phenolic acids and terpenes. The bioactivities of various extracts or individual compounds, both in vitro and in vivo, include antimicrobial, cytotoxic, antinociceptive, anti-
E. M. Zahran U. R. Abdelmohsen (&) M. S. Kamel Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, New Minia City 61111, Minia, Egypt e-mail: [email protected] U. R. Abdelmohsen S. Y. Desoukey M. A. Fouad M. S. Kamel Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 615199, Egypt H. E. Khalil Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia
inflammatory, antihyperglycemic and antioxidant. This comprehensive review will serve as a database for future research and drug development from the genus Ocimum. Keywords Lamiaceae Ocimum Taxonomy Phytoconstituents Biological activities Abbreviations AAPH APCI-MS BW C-NMR CC CC50 DMBA DPPH 13
DW ED50 EGFR FW Gal GC/MS Glc GlcA 1 H
2,20 -Azobis (2-amidinopropane) dihydrochloride Atmospheric pressure chemical ionization mass spectrometry Body weight Carbon nuclear magnetic resonance Column chromatography Half cytotoxic concentration 7,12-Dimethylbenzo anthracene 2,2-Diphenyl-1-picryl-hydrazylhydrate Dry weight Half effective dose Epidermal growth factor receptor Fresh weight Galactose Gas chromatography/mass spectrometry Glucose Glucouronic acid Proton nuclear magnetic resonance
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Phytochem Rev
HIV HPTLC IC50 IC90 LC50 ICAP-AES Ip. LD50 LDL LIBS LMI% Me MES MI MIC lM NF-KB OMe OSCC Pg PGE2 PhAs RAP Rha SAR UPLC–ESI– MS/MS VLDL ZOI Xyl
Human immunodeficiency virus High performance thin layer chromatography 50% Inhibitory concentration 90% Inhibitory concentration 50% Lethal concentration Inductively coupled argon plasma atomic spectroscopy Intraperitoneal 50% Lethal dose Low density lipoproteins Laser induced breakdown spectroscopy Percentage leucocyte migration inhibition Methyl Maximal electric shock Maxima
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