Clindamycin
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Delayed-type drug hypersensitivity reactions: 9 case reports In a case series of 87 patients investigated between 1999 and 2019, 9 patients (1 male patient and 8 female patients) were described [6 patients aged 31–64 years, 2 patients in their 60s or 80s and a girl child; exact ages of 3 patients not stated], who developed delayed-type drug hypersensitivity reactions (DTHs) in the form of acute-generalised exanthematous pustulosis (AGEP), maculopapular exanthema (MPE) or DRESS syndrome during treatment with clindamycin [not all indications stated; routes, dosages, durations of treatments to reactions onsets and outcomes not stated]. The patients had received treatment with clindamycin for erysipelas (3 patients), mastitis (1 patient), spider bite (1 patient), peritonsillar abscess (1 patient), dental implant (1patient) and for unknown reasons (2 patients). Thereafter, in April 1999 to September 2019 [date not specified in one patient], they developed DHT in the form of AGEP (2 patients), MPE (6 patients) and DRESS syndrome (1 patient). After 2–28 months of the reaction, they underwent a patch test to confirm the DHT using clindamycin [clindamycin hydrochloride] 10% pet. and prepared lege artis from the powder of the commercialised drug clindamycin [Dalacin-C]. The results of patch test with clindamycin were positive on day 2 and day 4 in 7 patients, and was negative on day 2 and positive on day 4 in 2 patients. In 6 of the 9 patients, the other relevant patch tested drugs were ceftriaxone, pseudoephedrine, minocycline, levofloxacin, pantoprazole, amoxicillin, clarithromycin, ampicillin, other unspecified β-lactams-quinolones or benzylpenicillin with negative or positive results. In 5 of the 9 patients, the prick and intradermal tests were performed with unspecified β-Lactam antibiotics, moxifloxacin, clindamycin, amoxicillin or cefuroxime with negative or positive results. Gilissen L, et al. Utility of patch testing for the diagnosis of delayed-type drug hypersensitivity reactions to clindamycin. Contact Dermatitis 83: 237-239, No. 3, Sep 2020. Available from: URL: http://doi.org/10.1111/cod.13575 803500977
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Reactions 12 Sep 2020 No. 1821
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