Cross-linked poly(vinyl alcohol) nanofibers as drug carrier of clindamycin
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Cross‑linked poly(vinyl alcohol) nanofibers as drug carrier of clindamycin Sara Nadem1 · Hakimeh Ziyadi2 · Malak Hekmati2 · Mitra Baghali1 Received: 14 April 2019 / Revised: 9 November 2019 / Accepted: 20 November 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract Given the importance of nanofibers in the field of pharmaceutical sciences and drug delivery applications, this study aimed to use poly(vinyl alcohol) (PVA) nanofibers as drug carriers for clindamycin. First, PVA solution was electrospun without drug to obtain electrospinning optimum condition of reference carrier. Then, 8% PVA solution containing 2% clindamycin was electrospun under optimum conditions at 20 kV voltage, 10 cm for nozzle-to-collector distance and an injection rate of 1 mL/h. In order to control drug release and improve the surface wet ability, the prepared polymeric nanofibers were cross-linked by glutaraldehyde. The prepared mats of nanofibers were characterized using scanning electron microscopy, atomic force microscopy, Fourier transform infrared and contact angle analysis. The in vitro drug release from nanofibers into the phosphate-buffered saline solution was measured by high-performance liquid chromatography at a wavelength of 210 nm. The in vitro drug release showed that cross-linked nanofibers had a lower drug release rate in a longer time. Keywords Nanofiber · Poly(vinyl alcohol) · Drug delivery · Cross-linking
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s0028 9-019-03027-z) contains supplementary material, which is available to authorized users. * Hakimeh Ziyadi [email protected] 1
Active Pharmaceutical Ingredients Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2
Department of Organic Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
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Polymer Bulletin
Introduction Nanofibers are a new generation of nanomaterials that are used in pharmacy, medicine, food industry, filtration, micro-coating of food additives and active packaging [1]. One of their most important applications is in the field of medicine, especially in drug release [2]. The best method for the fabrication of drug carrier nanofibers is electrospinning [3]. There are two general methods for constructing nanofibers. The first method is the production of nanofibers with an inherent property. The other one is the introduction of pharmaceuticals into an electrospinning solution [4]. The high loading capacity, high encapsulation efficiency, delivery of diverse therapies, surface modification capability, ease of operation and low cost are some appealing features of electrospinning used in drug delivery [5]. This method is used for the preparation of numerous drug delivery nanofibers such as synthetic or biopolymers [6]. One of the very important and applicable polymers as a drug carrier is poly(vinyl alcohol) (PVA) that forms nanofibrous freestanding mats during el
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