Clinical and imaging characteristics of primary hepatic sarcomatoid carcinoma and sarcoma: a comparative study
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RESEARCH ARTICLE
Open Access
Clinical and imaging characteristics of primary hepatic sarcomatoid carcinoma and sarcoma: a comparative study Dongli Shi1, Jun Sun1, Liang Ma2, Jing Chang3 and Hongjun Li1*
Abstract Background: Primary hepatic sarcomatous carcinoma (PHSC) and primary hepatic sarcoma (PHS) are rare malignancies with frequent overlap in both the clinic and radiology. No comparative study of these tumors for the restricted cases has previously been undertaken. The purpose of our study was to analyze the clinical and imaging features of PHSCs and PHSs, with an emphasis on particularities and similarities through a comparison of the two tumors. Methods: We retrospectively analyzed the clinical and imaging features of 39 patients with pathologically proven PHSCs (n = 23) and PHSs (n = 16) from four university centers over a 9-year period from 2010 to 2019. Univariate analyses were performed to determine the consistent and distinctive features. Results: The background of chronic hepatitis or cirrhosis was observed with a high frequency in both of PHSCs (73.7%) and PHSs (62.5%). Tumors with a diameter greater than 10 cm were significantly more common in PHSs than PHSCs (p = 0.043) and cystic masses were more detected in PHSs (P = 0.041). Both PHSCs and PHSs mainly presented hypovascularity (78.3% vs 81.3%). The ring hyper enhancement on the arterial phase (AP) and wash out were more frequently seen in PHSCs and the iso-hypo enhancement on the AP followed persistent or progressive enhancement was more commonly detected in PHSs (all, p < 0.05). Conclusion: PHSC and PHS generally present as mass lesions with hypovascularity. The ring hyper enhancement on the AP and wash out favor the diagnosis of PHSC. The large size greater than 10 cm, cystic lesion, iso-hypo persistent or progressive enhancement pattern might suggest the possibility of PHSs. Keywords: Liver tumor, Sarcomatous carcinoma, Sarcoma, Computed tomography, Magnetic resonance imaging
Background Primary hepatic sarcomatous carcinoma (PHSC) and primary hepatic sarcoma (PHS), are rare malignancies accounting for only 0.2% [1] and 1% [2] of primary malignant liver tumors, respectively. Sarcomatous carcinoma is defined as a tumor containing an intimate mixture of carcinomatous (either hepatocellular or * Correspondence: [email protected] 1 Department of Diagnostic Radiology, Beijing You’an Hospital, Capital Medical University, No.8, Xi Tou Tiao, You’anmen wai, Fengtai District, Beijing 100069, China Full list of author information is available at the end of the article
cholangiocellular) and sarcomatous elements. Sarcomatous change in hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICC) is defined as “sarcomatous HCC (S-HCC)” or “sarcomatous ICC (S-ICC)” in the World Health Organization (WHO) classification [3]. This entity is differentiated from a true hepatic sarcoma, such as undifferentiated embryonal sarcoma (UES), leiomyosarcoma (LS), malignant solitary fibrous tumor (SFT), epithelioid sarcoma (ES) and other interstitial tu
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