Sarcomatoid variant urothelial carcinoma of the bladder: a systematic review and meta-analysis of the clinicopathologica
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Cancer Cell International Open Access
REVIEW
Sarcomatoid variant urothelial carcinoma of the bladder: a systematic review and meta‑analysis of the clinicopathological features and survival outcomes Liangyou Gu1†, Qing Ai1†, Qiang Cheng1†, Xin Ma1, Baojun Wang1, Qingbo Huang1, Xintao Li2, Peng Zhang1, Kan Liu1, Xupeng Zhao3, Hongzhao Li1* and Xu Zhang1*
Abstract Background: A systematic review and meta-analysis was performed to compare the clinicopathological features and survival outcomes between sarcomatoid variant (SV)-urothelial carcinoma of the bladder (UCB) and conventional UCB (C-UCB). Methods: A comprehensive search of PubMed, Embase, and Cochrane Library was performed. Endpoints included clinicopathological features and survival outcomes (overall survival [OS], cancer-specific survival [CSS], and progression-free survival [PFS]). The survival benefits of neoadjuvant chemotherapy (NAC) or adjuvant chemotherapy (AC) for SV-UCB also have been studied. Results: A total of 8 observational studies were included. Patients with SV-UCB had a higher rate of ≥ stage pT3 (odds ratio [OR], 2.06; 95% confidence interval [CI], 1.64–2.59; p
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