Clinical effect of conbercept on improving diabetic macular ischemia by OCT angiography
- PDF / 5,578,632 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 105 Downloads / 181 Views
RESEARCH ARTICLE
Open Access
Clinical effect of conbercept on improving diabetic macular ischemia by OCT angiography Ziyi Zhu1, Youling Liang1, Bin Yan1, Zhishang Meng1, Kejun Long1, Yiwei Zhang1 and Jing Luo1,2*
Abstract Background: Varying degrees of macular ischemia generally occur in diabetic retinopathy (DR). This study aims to evaluate the effect of conbercept with 3+ pro re nata (PRN) on macular perfusion status in patients with diabetic macular edema (DME) and quantitatively assess changes in foveal avascular zone (FAZ) areas and capillary density in macular regions by applying optical coherence tomography angiography (OCTA). Methods: Fifty patients were divided into ischemic (n = 31) and non-ischemic (n = 19) groups according to the presence of ischemia on OCTA at baseline. All patients received intravitreal injections of 0.5 mg of conbercept with 3+ PRN principle. The FAZ areas and macular vessel density measured using OCTA were evaluated at baseline, 3 months, and 6 months after treatment in both groups. Results: At months 3 and 6, the FAZ area in the ischemic group changed from 0.510 ± 0.171 mm2 to 0.441 ± 0.158 mm2 then to 0.427 ± 0.153 mm2 (p = 0.003, p = 0.296); in the non-ischemic group, it remained stable (p = 0.269, p = 0.926). The superficial vessel density changed from 41.1 ± 4.1 to 42.5% ± 4.7% then to 42.6% ± 4.6% (p = 0.043, p = 0.812), and the deep vessel density changed from 40.7 ± 4.4 to 42.3% ± 3.6% then to 42.3% ± 4.7% (p = 0.072, p = 0.961) in the ischemic group. In the non-ischemic group, the superficial vessel density changed from 44.8 ± 3.2 to 46.0% ± 3.5% then to 45.7% ± 3.3% (p = 0.108, p = 0.666), whereas the deep vessel density changed from 43.6 ± 3.6 to 43.8% ± 3.2% then to 43.5% ± 4.5% (p = 0.882, p = 0.736). Reperfusion in macular nonperfusion areas was observed. Conclusion: Anti–vascular endothelial growth factor treatment may have a positive effect on macular perfusion status. Furthermore, OCTA had advantages in quantifying and calculating blood flow index in the study of macular perfusion status. Keywords: Diabetic retinopathy, Macular ischemia, Conbercept, OCT angiography
Background As extensively reported, the further the diabetic retinopathy (DR) progresses, the severer the condition of diabetic macular ischemia (DMI) in patients with DR [1, 2]. In macular ischemia, the structure of foveal capillary network is damaged. Such damage includes enlargement * Correspondence: [email protected] 1 Department of Ophthalmology, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Rd, Changsha, Hunan 410011, People’s Republic of China 2 Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan 410011, People’s Republic of China
and irregularity of the foveal avascular zone (FAZ) and appearance of macular nonperfusion (MNP), leading to macular function disturbance. According to ETDRS Report No. 11, the macular ischemia is defined as a FAZ area enlarging more than 1000 μm in greatest diameter (supposing the FAZ is round or oval), equaling to th
Data Loading...
