Clinical efficacy of optical coherence tomography in sellar mass lesions: a meta-analysis
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Clinical efficacy of optical coherence tomography in sellar mass lesions: a meta‑analysis Yuyu Chou1,2 · Bilei Zhang1,2 · Linyang Gan1,2 · Jin Ma1,2 · Yong Zhong1,2
© Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Although optical coherence tomography (OCT) of the eyes has been studied to detect and monitor sellar masses, there is no recommendation for selecting the most effective measurement of OCT in clinical practice. Thus, we conducted a meta-analysis to examine the efficacy of OCT in sellar mass lesions. Methods We conducted a literature search in PubMed and EMBASE through April 26, 2020. The primary outcomes were the thickness of the peripapillary retinal nerve fiber layer (pRNFL) and the macular ganglion cell complex (mGCC). The secondary outcomes included the thickness of the macular ganglion cell and inner plexiform layer (mGCIPL) and macular thickness. Random-effects models were used in all meta-analyses. Additionally, we conducted meta-regressions and subgroup analyses. Results We included 22 studies, involving 1347 eyes of patients and 1198 eyes of controls. When compared with the control group, the reductions in pRNFL, mGCC and macular thickness in the patient group were significantly different, whereas significant thinning of the mGCIPL was restricted to the nasal hemiretina. Furthermore, we found that before visual field (VF) defects occurred, significant thinning of the pRNFL and mGCC thickness could be detected by OCT. The change in OCT parameters also showed different patterns in different types of pituitary adenomas. Conclusions Sellar mass lesions were associated with the changes in OCT measurements. The characteristic patterns of the OCT parameters may refine the diagnostic accuracy. Moreover, the alterations of OCT metrics before VF defects indicate the efficacy of OCT in early detection. Different types of pituitary adenomas may vary in OCT measurements, and their specific features warrant further research efforts. Keywords Optical coherence tomography · Sellar mass lesions · Diagnosis · Early detection · Meta-analysis
Introduction Multiple sellar mass lesions, including pituitary adenoma (PA), craniopharyngioma and meningioma, can induce optic chiasm or optic nerve compression, resulting in various visual impairments [1]. In addition, due to the weak Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11102-020-01072-w) contains supplementary material, which is available to authorized users. * Yong Zhong [email protected] 1
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Beijing 100730, China
2
medial walls, tumors in the sellar region can also invade the cavernous sinuses and compress the III, IV, and VI cranial nerves, which facilitate diplopia and eye movement disorders [2]. Consistent with this not
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