Clinical features and efficacy of reperfusion therapy in minor ischemic stroke patients with atrial fibrillation
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Clinical features and efficacy of reperfusion therapy in minor ischemic stroke patients with atrial fibrillation Eiichi Nomura1 · Makoto Takemaru1 · Takahiro Himeno1 · Ryuhei Kono1 · Tomoko Fukushima2 · Shinzo Ota3
© Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The efficacy of reperfusion therapy (RT) using intravenous infusion of recombinant tissue plasminogen activator and/or endovascular therapy for minor ischemic stroke (MIS) has not yet been established. The present study aimed to elucidate the clinical features of MIS patients with atrial fibrillation (AF) and examine whether they could be potential candidates for RT. Data of MIS patients, defined as those with a score ≤ 5 on the National Institute of Health Stroke Scale, were extracted from patients admitted to our hospital between 2006 and 2018, and clinical characteristics were compared between the AF and non-AF groups. Thereafter, the impact of RT on outcomes in the AF- group was evaluated using the modified Rankin scale (mRS) score 3 months after onset and compared to that of standard medical therapy (SMT) using propensity score matching (PSM). Of 10,483 stroke patients, 3003 were shortlisted, and 457 AF patients and 2546 non-AF patients were finally selected. Patients in the AF group had more RT (13.3% vs. 5.7%, p
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