Impact of atrial fibrillation on the risk of ischemic stroke in patients on hemodialysis: BOREAS-HD3 Study
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ORIGINAL ARTICLE
Impact of atrial fibrillation on the risk of ischemic stroke in patients on hemodialysis: BOREAS‑HD3 Study Ayumu Kimura1 · Marenao Tanaka1 · Norihito Moniwa1 · Arata Osanami1 · Koki Abe1,2 · Daisuke Miyamori1 · Yufu Gocho1 · Satoru Shibata1,3 · Makoto Terasawa1 · Yusuke Okazaki1,3 · Tomohisa Yamashita1,4 · Masayuki Koyama1,5 · Masato Furuhashi1 · Hirofumi Ohnishi1,5 · Tetsuji Miura1 Received: 16 September 2020 / Accepted: 2 November 2020 © Japanese Society of Nephrology 2020
Abstract Background Atrial fibrillation (AF) is an established risk factor for ischemic stroke in a general population. However, its impact in patients on hemodialysis (HD), a group with a high risk for stroke, is still controversial. Here we examined this issue in a Japanese cohort. Methods This study was designed as a multicenter cohort study. HD patients (n = 1,067) were enrolled from 22 institutes in January 2009 and followed up for 3 years. Patients with missing data (n = 196) or kidney transplantation (n = 4) were excluded, and 867 patients contributed to the analysis of the risk of new-onset of ischemic stroke. Results At baseline, AF was observed in 123 patients (14.2%, AF group) and not in the others (n = 744: 85.8%, non-AF group). During a follow-up period of 31.3 months, the cumulative incidence rate for ischemic stroke was significantly higher in the AF group than in the non-AF group (6.5% vs. 2.9%, p
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