Clinical Genetics and Genomics of Aging
The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another
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Clinical Genetics and Genomics of Aging
Juan Carlos Gomez-Verjan Nadia Alejandra Rivero-Segura Editors
Clinical Genetics and Genomics of Aging
Editors Juan Carlos Gomez-Verjan Basic Sciencies Division National Institute of Geriatrics Ciudad de México Mexico
Nadia Alejandra Rivero-Segura Instituto Nacional de Geriatría (INGER) Ciudad de México Mexico
ISBN 978-3-030-40954-8 ISBN 978-3-030-40955-5 (eBook) https://doi.org/10.1007/978-3-030-40955-5 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
Medical care for older adults has long focused on preventing and treating chronic diseases and the conditions that come with them. But now, researchers and clinicians hope a new understanding can lead to better and more effective interventions by targeting the aging process itself rather than discrete conditions or concerns. Aging is complex and varies from one person to the other, but there’s a growing body of evidence that aging itself is driven by interconnected biological factors we call “hallmarks” or “pillars”; disrupting these hallmarks, which cover everything from the stability of our genes to ways our cells communicate, can contribute to chronic disease and frailty, which is why a better understanding of how they work is so important. Besides, how does aging affect the onset and progression of chronic disease? The work of many aging researchers has focused on studying the specific mechanisms that contribute to the aging process, and not so much on its effects on various diseases. However, age represents a major risk factor for several chronic diseases and conditions, including frailty and lack of resilience. Geroscience’s approach s
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