Genetics and Genomics of Neurobehavioral Disorders

In recent years, significant gains have been made in the cloning and identification of numerous genes that produce neurobehavioral disorders, as well as in the ability of neuropsychological tests to accurately assess and evaluate cognitive deficits and be

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ontemporary linical euroscience

Series Editors: Ralph Lydic and Helen A. Baghdoyan

Genetics and Genomics of Neurobehavioral Disorders edited by Gene S. Fisch, 2003 Sedation and Analgesia for Diagnostic and Therapeutic Procedures edited by Shobha Malviya, Norah N. Naughton, and Kevin K. Tremper, 2003 Neural Mechanisms of Anesthesia, edited by Joseph F. Antognini, Earl E. Carstens, and Douglas E. Raines, 2002 Glutamate and Addiction edited by Barbara Herman, 2002 Molecular Mechanisms of Neurodegenerative Diseases edited by Marie-Françoise Chesselet, 2000

C ontemporary Clinical Neuroscience

Genetics and Genomics of Neurobehavioral Disorders Edited by

Gene S. Fisch Department of Epidemiology and Public Health and the Child Study Center Yale University School of Medicine New Haven, CT

Springer Science+Business Media, LLC

© 2003 Springer Science+Business Media New York Originally published by Humana Press Inc in 2003

Softcover reprint of the hardcover 1st edition 2003

All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. The content and opinions expressed in this book are the sole work of the authors and editors, who have warranted due diligence in the creation and issuance of their work. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences arising from the information or opinions presented in this book and make no warranty, express or implied, with respect to its contents. This publication is printed on acid-free paper. ∞ ANSI Z39.48-1984 (American Standards Institute) Permanence of Paper for Printed Library Materials. Cover design by Patricia F. Cleary. Cover illustrations: Cranial computerized tomography in tuberous sclerosis (see Fig. 2, Chapter 7, p. 161) and subependymal giant cell astrocytoma by T1-weighted magnetic resonance imaging (see Fig. 3, Chapter 7, p. 162).

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Library of Congress Cataloging-in-Publication Data Genetics and genomics of neurobehavioral disorders / edited by Gene S. Fisch. p. cm. -- (Contemporary clinical neuroscience) Includes bibliographical references and index. ISBN 978-1-61737-322-0 ISBN 978-1-59259-353-8 (eBook) DOI 10.1007/978-1-59259-353-8 1. Neurobehavioral disorders--Genetic aspects. I. Fisch, Gene S. II. Series. RC455.4.G4 G493 2003 616.8’0442--dc21 2002068944

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