Clinical manifestations of Kawasaki disease in different age groups: retrospective data from Southwest China
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ORIGINAL ARTICLE
Clinical manifestations of Kawasaki disease in different age groups: retrospective data from Southwest China Lianjie Shi 1,2 & Jianhong Li 3 & Di Qie 2 & Xintian Hua 2 & Jinyong Pan 4 & Xiaoqing Shi 2 & Liang Zhao 2 & Li Li 5 & Jiangtao Li 6 & Hanmin Liu 2 & Lina Qiao 2 Received: 6 December 2019 / Revised: 17 March 2020 / Accepted: 23 March 2020 # International League of Associations for Rheumatology (ILAR) 2020
Abstract Objectives The aim of the present study is to identify the clinical manifestations and laboratory findings of children with Kawasaki disease (KD) in different age groups and to recognize and treat KD in a timely manner. Methods A total of 213 children with KD were divided into the following age groups: (1) infants, (2) toddlers, and (3) preschool age. Retrospective analysis of clinical data was performed among the groups. Categorical data were statistically compared by Chi-square analysis, and measurement data were compared using one-way ANOVA analysis. Results Our study showed that (1) cough (40.5%), diarrhea (16.9%), and vomiting (8.5%) were also very common in KD patients. (2) Patients in the infant group more commonly developed cough and diarrhea, but were less frequently documented with lymphadenopathy and skin rash. (3) Elevation of platelets was more common in the infant group. When urine tests were compared among the three groups, the toddler group had a higher proportion of sterile pyuria, and infants younger than 1 year old had a lower proportion of proteinuria and positive urine ketones. Conclusion Cough, diarrhea, vomiting, and sterile pyuria were very common in infant KD patients less than 1 year old. They should be noted in patients with suspected KD for earlier diagnosis and timely treatments. Key Points • Patients with Kawasaki disease (KD) in different age groups showed different clinical manifestations and laboratory findings. • Cough, diarrhea, vomiting, and sterile pyuria were very common in infant KD patients less than 1 year old. • Paying more attentions to respiratory, gastrointestinal, and urinary manifestations or abnormalities might be helpful for earlier diagnosis of KD, especially incomplete KD, though they were not list in the diagnostic criteria.
Keywords Age group . Kawasaki disease . Laboratory parameters . Manifestation
Lianjie Shi and Jianhong Li contributed equally to this work. * Hanmin Liu [email protected] * Lina Qiao [email protected] 1
Department of Rheumatology and Immunology, Peking University International Hospital, Beijing 102206, China
2
Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, NO. 20, section 3, Renmin South Road, Chengdu 610041, Sichuan, China
3
Department of Nuclear Medicine, Peking University International Hospital, Beijing 102206, China
4
Department of Pediatrics, The First Affiliated Hospital of Medical College, Shihezi University, Shihezi 832008, China
5
Department of Rheumatolog
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