Clinical and CT features of the COVID-19 infection: comparison among four different age groups
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RESEARCH PAPER
Clinical and CT features of the COVID‑19 infection: comparison among four different age groups Wei Li1 · Yijie Fang1 · Jianwei Liao1 · Wenjun Yu1 · Lin Yao1 · Huaqian Cui2 · Xiang Zeng3 · Shaolin Li1 · Chuan Huang4 Received: 2 May 2020 / Accepted: 2 July 2020 © European Geriatric Medicine Society 2020
Key summary points Aim The aim of this study was to compare and analyze the clinical and CT features of coronavirus disease 2019 (COVID19) in four different age groups (children, young adults, middle age, and senior). Findings Seniors were found to have a higher incidence of the highest clinical classification (severe or critical), large/multiple ground-glass opacity, and involvement of four or five lung lobes in these four groups. Message Older patients of COVID-19 are more likely to be infected with a larger number of lung lobes and more severe manifestations as visualized by CT. Abstract Purpose To compare and analyze the clinical and CT features of coronavirus disease 2019 (COVID-19) among four different age groups. Methods 97 patients (45 males, 52 females, mean age, 66.2 ± 5.0) with chest CT examination and positive reverse transcriptase-polymerase chain reaction test (RT-PCR) from January 17, 2020 to February 21, 2020 were retrospectively studied. The patients were divided into four age groups (children [0–17 years], young adults [18–44 years], middle age [45–59 years], and senior [≥ 60 years]) according to their age after the diagnosis was made based on PCR test and clinical symptoms. Results Comorbidities such as hypertension, diabetes mellitus, and heart disease are more common in the senior group. Cluster onset (two or more confirmed cases in a small area) is more common in the children group and senior group. Older patients were found to have a higher incidence of the highest clinical classification (severe or critical) in these four groups. Senior patients have a higher incidence of large/multiple ground-glass opacity (GGO). Child patients are mostly negative for chest CT or with involvement of only one lobe of the lung; while in older patients, there was a higher incidence of involvement of four or five lung lobes. The frequency of lobe involvement was also found to have significant differences in the four age groups.
Wei Li and Yijie Fang contributed equally to this work. * Shaolin Li [email protected] 1
Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, The Fifth Affiliated Hospital, Sun Yat-Sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China
2
Department of Medical Affairs, The Fifth Affiliated Hospital, Sun Yat-Sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, China
3
Zhuhai Center for Disease Control and Prevention, 9 Weikang Rd, Nanping Town, Zhuhai, Guangdong Province, China
4
Departments of Radiology, Psychiatry, Stony Brook Medicine, Stony Brook, NY 11794, USA
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Vol.:(0123456789)
European Geriatric Medicine
Conclusion The clinic
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