Clopidogrel
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Sweet syndrome: case report A 71-year-old woman developed Sweet’s syndrome during antiplatelet therapy with clopidogrel. The woman presented to hospital with multiple progressive painful skin lesions. She had undergone percutaneous coronary intervention and stenting of the left anterior descending artery. She had been receiving clopidogrel [dosage and route not stated] and aspirin for 10 days. On presentation, diffuse joint pain and erythematous conjunctiva were also noted. Her medical history was significant for rheumatoid arthritis and haemodialysis for end-stage renal disease. On physical examination, she had tender haemorrhagic bullae in all the extremities without skin desquamation. Bullous drug eruption was considered as a differential diagnosis based on her physical examination findings. A skin biopsy showed a diffuse neutrophilic dermatosis, consistent with Sweet’s syndrome. The woman was initiated on high-dose steroids [specific drug not stated] and clopidogrel was replaced by prasugrel, following which her symptoms improved. She was then discharged with plans to taper the steroid dosage. Walterscheid B, et al. Clopidogrel-induced sweet syndrome: severe dermatological complication after percutaneous coronary intervention. European Heart Journal : 2020. 803504737 Available from: URL: http://doi.org/10.1093/eurheartj/ehaa656
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Reactions 3 Oct 2020 No. 1824
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