Clozapine
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Agranulocytosis, thrombocytopenia and neutropenia: 4 case reports In a retrospective study conducted in India involving 333 patients whose data was maintained in a registry since 2010, 4 patients [ages and sexes not stated] were described, of whom 3 patients developed thrombocytopenia, and the remaining one patient developed agranulocytosis and neutropenia during treatment with clozapine for psychiatric disorders [routes and duration of treatments to reaction onsets not stated; not all dosages and outcomes stated]. The patients, who had psychiatric disorders, started receiving clozapine. One of the four patients received clozapine at a dose of 150 mg/day. Of the four patients, 3 patients developed thrombocytopenia as a side effect. The remaining one patient (receiving clozapine 150 mg/day), developed agranulocytosis and neutropenia as side effects. Of the 3 patients, who developed thrombocytopenia, two patients were receiving valproate as a concomitant therapy. In one of the 3 patients, who developed thrombocytopenia, platelet count normalised following clozapine cessation. Grover S, et al. Haematological side effects associated with clozapine: A retrospective study from India. Asian Journal of Psychiatry 48: 13 Feb 2020. Available from: URL: 803448487 http://doi.org/10.1016/j.ajp.2019.101906
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Reactions 25 Jan 2020 No. 1788
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