Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials
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REVIEW
Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials Abolfazl Akbari 1 & Gholam Reza Mobini 2 & Shahram Agah 1 & Mojgan Morvaridzadeh 3 & Amirhossein Omidi 3 & Eric Potter 4 & Siavash Fazelian 5 & Seyed Hossein Ardehali 6 & Elnaz Daneshzad 7 & Sadegh Dehghani 8 Received: 18 February 2020 / Accepted: 26 May 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Oxidative stress (OS) is associated with several chronic complications and diseases. The use of coenzyme Q10 (CoQ10) as an adjuvant treatment with routine clinical therapy against metabolic diseases has shown to be beneficial. However, the impact of CoQ10 as a preventive agent against OS has not been systematically investigated. Methods A systematic literature search was performed using the PubMed, SCOPUS, EMBASE, and Cochrane Library databases to identify randomized clinical trials evaluating the efficacy of CoQ10 supplementation on OS parameters. Standard mean differences and 95% confidence intervals were calculated for net changes in OS parameters using a random-effects model. Results Seventeen randomized clinical trials met the eligibility criteria to be included in the meta-analysis. Overall, CoQ10 supplementation was associated with a statistically significant decrease in malondialdehyde (MDA) (SMD − 0.94; 95% CI − 1.46, − 0.41; I2 = 87.7%) and a significant increase in total antioxidant capacity (TAC) (SMD 0.67; 95% CI 0.28, 1.07; I2 = 74.9%) and superoxide dismutase (SOD) activity (SMD 0.40; 95% CI 1.12, 0.67; I2 = 9.6%). The meta-analysis found no statistically significant impact of CoQ10 supplementation on nitric oxide (NO) (SMD − 1.40; 95% CI − 0.12, 1.93; I2 = 92.6%), glutathione (GSH) levels (SMD 0.41; 95% CI − 0.09, 0.91; I2 = 70.0%), catalase (CAT) activity (SMD 0.36; 95% CI − 0.46, 1.18; I2 = 90.0%), or glutathione peroxidase (GPx) activities (SMD − 1.40; 95% CI: − 0.12, 1.93; I2 = 92.6%). Conclusion CoQ10 supplementation, in the tested range of doses, was shown to reduce MDA concentrations, and increase TAC and antioxidant defense system enzymes. However, there were no significant effects of CoQ10 on NO, GSH concentrations, or CAT activity. Keywords Coenzyme Q10 . Oxidative stress . Malondialdehyde . Glutathione peroxidase
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00228-020-02919-8) contains supplementary material, which is available to authorized users. * Sadegh Dehghani [email protected] Abolfazl Akbari [email protected] Gholam Reza Mobini [email protected]
1
2
Cellular & Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences (SkUMS), Shahrekord, Iran
3
Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
4
Baylor Scott & White Research Institute, Dallas, Texas, USA
Mojgan Morvaridzadeh [email protected]
5
Clinical Re
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